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- W2892276714 abstract "Abstract Background: Acute mountain sickness (AMS) is the most common form of altitude illness. Several risk factors have been suggested in the literature: some (absolute altitude, rapidity of ascent, individual susceptibility, lack of acclimatization) are well established, others are more debated. Limited sample size may have reduced the power of previous studies to identify these alternative risk factors for AMS Objectives: To study potential determinants of AMS in a large sample. Methods: Data from three retrospective observational cross-sectional studies conducted in Nepal in 1986, 1998 and 2010 with a total of 956 trekkers stopping in Manang or in Muktinath (3500 m), crossing a 5400 m high mountain pass, Thorong-La. Age, sex, height and weight, BMI, health history, nationality, smoking status, profession, previous altitude experience, group sizes, rate of ascent, medications used and carried and self-quantification of AMS symptoms (ESQ-III questionnaire) were analyzed. An AMS-C score of ≥ 0.7 was considered to identify subjects suffering from AMS. Results: Prevalence of AMS was 32%. Using a bivariate analysis, sex (p = 0.002), age (p = < 0.001), height (p =0.012), weight (p = 0.033), previous altitude experience (p = 0.004) and group size (p = 0.010) were significantly associated with AMS. Age (odds ratio [OR], 0.970; 95% confidence interval, 0.954 to 0.986; p < 0.001), female sex [OR= 1.610 (1.163 to 2.229) p = 0.004] and body mass index [OR=1.099 (1.030 to 1.172) p = 0.004] were significant predictors of AMS when using multivariate analyses. Conclusion: Consistent with pre-existing literature, young age and female sex were significant risk factors of AMS also in our cohort. Although debated in the literature, increasing BMI represented a significant AMS predictor in our population." @default.
- W2892276714 created "2018-09-27" @default.
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- W2892276714 date "2016-01-01" @default.
- W2892276714 modified "2023-09-27" @default.
- W2892276714 title "Risk Factors for Acute Mountain Sickness: Retrospective Cohort Study in Nepal." @default.
- W2892276714 hasPublicationYear "2016" @default.
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