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• W2892280991 abstract "Context.— Follicular lymphoma is a common small B-cell lymphoma, likely to be encountered by any practicing pathologist, regardless of specialty. Although the features of typical follicular lymphoma are well known and in most instances easily identifiable, there are lesser-appreciated morphologic appearances that can raise alternative diagnostic possibilities. The limited tissue available in core needle biopsies can make it additionally challenging to thoroughly evaluate those features in the context of architecture. Furthermore, ancillary testing including immunohistochemistry and molecular/genetic analysis do not always show classic findings and may pose additional challenges to interpretation. Objectives.— To review the morphologic features of follicular lymphoma with a discussion of morphologic variants and mimics; to discuss pitfalls of ancillary testing and provide the practicing pathologist with an appropriate context for interpretation of immunohistochemical and molecular/genetic studies when follicular lymphoma is part of the differential diagnosis; and to propose diagnostic strategies when there is limited tissue for evaluation. Data Sources.— We used examples of follicular lymphoma from our institution as well as a review of the literature, with a focus on the diagnostic aspects that are broadly relevant to a general pathology practice. Conclusions.— Follicular lymphoma can occasionally present with atypical morphologic, immunohistochemical, or molecular/genetic features. In particular, those findings can be difficult to interpret in the setting of a limited tissue sample. Awareness of those possibilities will help guide the pathologist to a more accurate and precise diagnosis." @default.
• W2892280991 created "2018-09-27" @default.
• W2892280991 creator A5018984989 @default.
• W2892280991 creator A5021866052 @default.
• W2892280991 creator A5025326711 @default.
• W2892280991 date "2018-09-17" @default.
• W2892280991 modified "2023-10-11" @default.
• W2892280991 title "Follicular Lymphoma Diagnostic Caveats and Updates" @default.
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• W2892280991 doi "https://doi.org/10.5858/arpa.2018-0217-ra" @default.
• W2892280991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30221980" @default.
• W2892280991 hasPublicationYear "2018" @default.
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