FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892282323> ?p ?o ?g. }

• W2892282323 endingPage "328" @default.
• W2892282323 startingPage "303" @default.
• W2892282323 abstract "Solid drug delivery systems are crucial formulations for the oral route. In such systems, particle size and polymorphism have a strong impact on drug dissolution and on drug absorption. Starting from the role of particle size in dissolution rate, the Noyes-Whitney equation, the modified form by Nernst-Brunner and the cube root equation are here described. According to these equations diffusion of a solute through a boundary layer around the particles is the rate limiting step for both drug dissolution and absorption and, thus, depends on the specific (external) surface area of the particles, the diffusion coefficient of the dissolved drug, the thickness of the boundary layer and the drug solubility. In relation to this, good wetting of the particle surface by the surrounding liquid and adequate particle dispersion play an essential role. Information from dissolution rates suggests that the thickness of the boundary layer is constant for larger particle sizes, but dependent upon size for smaller particles. Given the larger surface area of smaller particles, the attention has been directed to nanosystems and on their relevance to the bioavailability of poorly soluble drugs. A second advantage of such drug systems is that solubility increases on decreasing particle size, according to the Freundlich–Ostwald equation. The impact of polymorphism, pseudopolymorphism and amorphous form on drug dissolution and bioavailability is also described. Since dissolution and absorption are closely related, the effect of particle size and polymorphism on drug absorption is described. Moreover, regulatory implications of particle size and polymorphism are reviewed." @default.
• W2892282323 created "2018-09-27" @default.
• W2892282323 creator A5023781229 @default.
• W2892282323 creator A5030204724 @default.
• W2892282323 creator A5035322997 @default.
• W2892282323 creator A5053035943 @default.
• W2892282323 date "2018-01-01" @default.
• W2892282323 modified "2023-10-16" @default.
• W2892282323 title "Effects of Particle Size, Surface Nature and Crystal Type on Dissolution Rate" @default.
• W2892282323 cites W1264540065 @default.
• W2892282323 cites W1492356062 @default.
• W2892282323 cites W1492714637 @default.
• W2892282323 cites W1498305210 @default.
• W2892282323 cites W1517266424 @default.
• W2892282323 cites W1522767714 @default.
• W2892282323 cites W1573530222 @default.
• W2892282323 cites W1596960175 @default.
• W2892282323 cites W1603855465 @default.
• W2892282323 cites W1968431678 @default.
• W2892282323 cites W1970084786 @default.
• W2892282323 cites W1973960007 @default.
• W2892282323 cites W1975230163 @default.
• W2892282323 cites W1980535921 @default.
• W2892282323 cites W1982460552 @default.
• W2892282323 cites W1991051273 @default.
• W2892282323 cites W1991916654 @default.
• W2892282323 cites W1994787771 @default.
• W2892282323 cites W1995008519 @default.
• W2892282323 cites W1997764055 @default.
• W2892282323 cites W1999724659 @default.
• W2892282323 cites W2001481495 @default.
• W2892282323 cites W2001596955 @default.
• W2892282323 cites W2009537932 @default.
• W2892282323 cites W2009990878 @default.
• W2892282323 cites W2016971948 @default.
• W2892282323 cites W2025148531 @default.
• W2892282323 cites W2026939990 @default.
• W2892282323 cites W2030951340 @default.
• W2892282323 cites W2036630386 @default.
• W2892282323 cites W2039521277 @default.
• W2892282323 cites W2041317416 @default.
• W2892282323 cites W2049599102 @default.
• W2892282323 cites W2054253681 @default.
• W2892282323 cites W2056211275 @default.
• W2892282323 cites W2063288695 @default.
• W2892282323 cites W2070825233 @default.
• W2892282323 cites W2080431921 @default.
• W2892282323 cites W2086130473 @default.
• W2892282323 cites W2087234082 @default.
• W2892282323 cites W2088839933 @default.
• W2892282323 cites W2099419252 @default.
• W2892282323 cites W2107575597 @default.
• W2892282323 cites W2112429056 @default.
• W2892282323 cites W2156829937 @default.
• W2892282323 cites W2479885206 @default.
• W2892282323 cites W2611501754 @default.
• W2892282323 cites W2611527592 @default.
• W2892282323 cites W4109169 @default.
• W2892282323 cites W4251505294 @default.
• W2892282323 cites W4376849571 @default.
• W2892282323 doi "https://doi.org/10.1007/978-3-319-94174-5_8" @default.
• W2892282323 hasPublicationYear "2018" @default.
• W2892282323 type Work @default.
• W2892282323 sameAs 2892282323 @default.
• W2892282323 citedByCount "4" @default.
• W2892282323 countsByYear W28922823232020 @default.
• W2892282323 countsByYear W28922823232021 @default.
• W2892282323 countsByYear W28922823232022 @default.
• W2892282323 crossrefType "book-chapter" @default.
• W2892282323 hasAuthorship W2892282323A5023781229 @default.
• W2892282323 hasAuthorship W2892282323A5030204724 @default.
• W2892282323 hasAuthorship W2892282323A5035322997 @default.
• W2892282323 hasAuthorship W2892282323A5053035943 @default.
• W2892282323 hasConcept C111368507 @default.
• W2892282323 hasConcept C121332964 @default.
• W2892282323 hasConcept C125287762 @default.
• W2892282323 hasConcept C127313418 @default.
• W2892282323 hasConcept C127413603 @default.
• W2892282323 hasConcept C147789679 @default.
• W2892282323 hasConcept C155574463 @default.
• W2892282323 hasConcept C159467904 @default.
• W2892282323 hasConcept C159985019 @default.
• W2892282323 hasConcept C171250308 @default.
• W2892282323 hasConcept C178790620 @default.
• W2892282323 hasConcept C181389837 @default.
• W2892282323 hasConcept C185592680 @default.
• W2892282323 hasConcept C187530423 @default.
• W2892282323 hasConcept C192562407 @default.
• W2892282323 hasConcept C2778517922 @default.
• W2892282323 hasConcept C2779227376 @default.
• W2892282323 hasConcept C42360764 @default.
• W2892282323 hasConcept C60644358 @default.
• W2892282323 hasConcept C65177555 @default.
• W2892282323 hasConcept C86803240 @default.
• W2892282323 hasConcept C88380143 @default.
• W2892282323 hasConcept C97355855 @default.
• W2892282323 hasConceptScore W2892282323C111368507 @default.
• W2892282323 hasConceptScore W2892282323C121332964 @default.

• next