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- W2892282621 endingPage "7322" @default.
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- W2892282621 abstract "Significance Microtubule polymerization dynamics are fundamental to cell migration and cell division, where they are targets for chemotherapy drugs. Despite significant progress, the precise structural and biochemical events occurring at growing microtubule tips are not well defined, and better understanding is necessary for discriminating mechanisms of microtubule dynamics regulation in cells. Here, we visualize individual tubulin subunits reversibly and irreversibly interacting with dynamic microtubule tips, and thereby directly measure tubulin plus-tip kinetics. By analyzing plus-tip residence times of wild-type and mutant tubulin, we characterize the relative contributions of longitudinal (along protofilaments) and lateral (between protofilaments) bond energies to microtubule growth. This work provides insight into microtubule tip structure and potential modes of microtubule dynamics regulation." @default.
- W2892282621 created "2018-09-27" @default.
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- W2892282621 date "2019-02-25" @default.
- W2892282621 modified "2023-09-25" @default.
- W2892282621 title "Direct observation of individual tubulin dimers binding to growing microtubules" @default.
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- W2892282621 doi "https://doi.org/10.1073/pnas.1815823116" @default.
- W2892282621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6462098" @default.
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