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- W2892283512 abstract "The role of the endocrine hormone leptin in controlling energy homeostasis in the hypothalamus are well documented. However the CNS targets for leptin are not restricted to the hypothalamus as a high density of leptin receptors are also expressed in several parts of the brain involved in higher cognitive functions including the hippocampus. Numerous studies have identified that in the hippocampus, leptin has cognitive enhancing actions as exogenous application of this hormone facilitates hippocampal-dependent learning and memory, whereas lack or insensitivity to leptin results in significant memory deficits. Leptin also markedly influences some of the main cellular changes that are involved in learning and memory including NMDA-receptor dependent synaptic plasticity and glutamate receptor trafficking. Like other metabolic hormones, there is a significant decline in neuronal sensitivity to leptin during the ageing process. Indeed, the capacity of leptin to modulate the functioning of hippocampal synapses is substantially reduced in aged compared to adult tissue. Clinical studies have also identified an association between circulating leptin levels and the risk of certain neurodegenerative disorders such as Alzheimer's disease (AD). In view of this, targeting leptin and/or its receptor/signaling mechanisms may be an innovative approach for developing therapies to treat AD. In support of this, accumulating evidence indicates that leptin has cognitive enhancing and neuroprotective actions in various models of AD. Here we assess recent evidence that supports an important regulatory role for leptin at hippocampal CA1 synapses, and we discuss how age-related alterations in this hormonal system influences neurodegenerative disease." @default.
- W2892283512 created "2018-09-27" @default.
- W2892283512 creator A5012011678 @default.
- W2892283512 creator A5074072743 @default.
- W2892283512 date "2018-10-16" @default.
- W2892283512 modified "2023-10-17" @default.
- W2892283512 title "Regulation of Hippocampal Synaptic Function by the Metabolic Hormone, Leptin: Implications for Health and Neurodegenerative Disease" @default.
- W2892283512 cites W1486463812 @default.
- W2892283512 cites W1498003589 @default.
- W2892283512 cites W1547411530 @default.
- W2892283512 cites W1604789859 @default.
- W2892283512 cites W1607364459 @default.
- W2892283512 cites W1863214859 @default.
- W2892283512 cites W1876061808 @default.
- W2892283512 cites W1881846578 @default.
- W2892283512 cites W1906761430 @default.
- W2892283512 cites W1965966174 @default.
- W2892283512 cites W1966556007 @default.
- W2892283512 cites W1969688059 @default.
- W2892283512 cites W1970310716 @default.
- W2892283512 cites W1971566977 @default.
- W2892283512 cites W1972469557 @default.
- W2892283512 cites W1978275387 @default.
- W2892283512 cites W1979296460 @default.
- W2892283512 cites W1987248538 @default.
- W2892283512 cites W1990497167 @default.
- W2892283512 cites W1990937715 @default.
- W2892283512 cites W1991408305 @default.
- W2892283512 cites W1993782794 @default.
- W2892283512 cites W1998650202 @default.
- W2892283512 cites W1998887119 @default.
- W2892283512 cites W2001887191 @default.
- W2892283512 cites W2002209256 @default.
- W2892283512 cites W2007675951 @default.
- W2892283512 cites W2010419244 @default.
- W2892283512 cites W2015022239 @default.
- W2892283512 cites W2019752999 @default.
- W2892283512 cites W2020897081 @default.
- W2892283512 cites W2024567938 @default.
- W2892283512 cites W2025308399 @default.
- W2892283512 cites W2028594041 @default.
- W2892283512 cites W2034340220 @default.
- W2892283512 cites W2038295103 @default.
- W2892283512 cites W2038972984 @default.
- W2892283512 cites W2044248209 @default.
- W2892283512 cites W2045931153 @default.
- W2892283512 cites W2047334134 @default.
- W2892283512 cites W2049511526 @default.
- W2892283512 cites W2049804246 @default.
- W2892283512 cites W2051383271 @default.
- W2892283512 cites W2057359899 @default.
- W2892283512 cites W2057528564 @default.
- W2892283512 cites W2061507736 @default.
- W2892283512 cites W2062608519 @default.
- W2892283512 cites W2064127993 @default.
- W2892283512 cites W2064859339 @default.
- W2892283512 cites W2065169750 @default.
- W2892283512 cites W2067487342 @default.
- W2892283512 cites W2074754570 @default.
- W2892283512 cites W2079302576 @default.
- W2892283512 cites W2079560849 @default.
- W2892283512 cites W2082151254 @default.
- W2892283512 cites W2085255353 @default.
- W2892283512 cites W2086518954 @default.
- W2892283512 cites W2087277393 @default.
- W2892283512 cites W2091643921 @default.
- W2892283512 cites W2096397785 @default.
- W2892283512 cites W2101746873 @default.
- W2892283512 cites W2106464041 @default.
- W2892283512 cites W2107808842 @default.
- W2892283512 cites W2109727228 @default.
- W2892283512 cites W2111732109 @default.
- W2892283512 cites W2115904465 @default.
- W2892283512 cites W2120023895 @default.
- W2892283512 cites W2125510262 @default.
- W2892283512 cites W2128828378 @default.
- W2892283512 cites W2137667246 @default.
- W2892283512 cites W2137970237 @default.
- W2892283512 cites W2145984134 @default.
- W2892283512 cites W2152936641 @default.
- W2892283512 cites W2154006548 @default.
- W2892283512 cites W2157702984 @default.
- W2892283512 cites W2158894504 @default.
- W2892283512 cites W2161461930 @default.
- W2892283512 cites W2167153356 @default.
- W2892283512 cites W2170182827 @default.
- W2892283512 cites W2170227659 @default.
- W2892283512 cites W2222537613 @default.
- W2892283512 cites W2334337188 @default.
- W2892283512 cites W2417724549 @default.
- W2892283512 cites W2520040696 @default.
- W2892283512 cites W2748617320 @default.
- W2892283512 cites W2749718288 @default.
- W2892283512 cites W2774416390 @default.
- W2892283512 cites W2803732321 @default.
- W2892283512 cites W4210288756 @default.
- W2892283512 cites W4230038754 @default.
- W2892283512 cites W4230871683 @default.
- W2892283512 cites W4232848541 @default.
- W2892283512 cites W4244991868 @default.