Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892284745> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2892284745 abstract "Background: The transcription factor STAT3 has a prominent innate immunity effect on cancer progression. We determined the regulation of STAT3 in the immunophenotype modulation of macrophages from M1 to M2 induced by the cell culture supernatant of the prostate cancer line PC3. Methods: Monocyte-macrophages from healthy donors were cultured in the supernatant of PC3 cells, membrane proteins and intracytoplasmic and phosphorylated STAT3 were measured using flow cytometry, and cytokines and growth factors were studied using luminescence. Cytotoxicity and nitric oxide were evaluated via colorimetric assays. Results: The supernatant of prostate tumor PC3 cells effectively induced macrophages toward an M2 profile, and the expression of phosphorylated STAT3 in the monocytes-macrophages notably increased. In the group of monocytes-macrophages treated with an STAT3 inhibitor, the macrophages were induced towards an M1 phenotype. Conclusions: In this study, we show that the secretion profile of PC3 prostate cancer cells induces a change in macrophage phenotype from M1 to M2, and this phenomenon is related to phosphorylation of the transcription factor STAT3. Citation Format: Raul Solis, Alejandro Bravo, Jr., Georgina Hernandez, Alejandro Bravo. Regulation of immunophenotype modulation of monocytes-macrophages from M1 to M2 by prostate cancer cell culture supernatant via the transcription factor STAT3 [abstract]. In: Proceedings of the AACR Special Conference: Prostate Cancer: Advances in Basic, Translational, and Clinical Research; 2017 Dec 2-5; Orlando, Florida. Philadelphia (PA): AACR; Cancer Res 2018;78(16 Suppl):Abstract nr A097." @default.
- W2892284745 created "2018-09-27" @default.
- W2892284745 creator A5041498623 @default.
- W2892284745 creator A5051277193 @default.
- W2892284745 creator A5053389464 @default.
- W2892284745 date "2018-08-14" @default.
- W2892284745 modified "2023-09-27" @default.
- W2892284745 title "Abstract A097: Regulation of immunophenotype modulation of monocytes-macrophages from M1 to M2 by prostate cancer cell culture supernatant via the transcription factor STAT3" @default.
- W2892284745 doi "https://doi.org/10.1158/1538-7445.prca2017-a097" @default.
- W2892284745 hasPublicationYear "2018" @default.
- W2892284745 type Work @default.
- W2892284745 sameAs 2892284745 @default.
- W2892284745 citedByCount "0" @default.
- W2892284745 crossrefType "proceedings-article" @default.
- W2892284745 hasAuthorship W2892284745A5041498623 @default.
- W2892284745 hasAuthorship W2892284745A5051277193 @default.
- W2892284745 hasAuthorship W2892284745A5053389464 @default.
- W2892284745 hasConcept C104317684 @default.
- W2892284745 hasConcept C11960822 @default.
- W2892284745 hasConcept C121608353 @default.
- W2892284745 hasConcept C126322002 @default.
- W2892284745 hasConcept C153911025 @default.
- W2892284745 hasConcept C196166836 @default.
- W2892284745 hasConcept C202751555 @default.
- W2892284745 hasConcept C203014093 @default.
- W2892284745 hasConcept C2778923194 @default.
- W2892284745 hasConcept C2779244956 @default.
- W2892284745 hasConcept C2779723316 @default.
- W2892284745 hasConcept C2780192828 @default.
- W2892284745 hasConcept C2781184567 @default.
- W2892284745 hasConcept C502942594 @default.
- W2892284745 hasConcept C54355233 @default.
- W2892284745 hasConcept C553184892 @default.
- W2892284745 hasConcept C55493867 @default.
- W2892284745 hasConcept C71924100 @default.
- W2892284745 hasConcept C81885089 @default.
- W2892284745 hasConcept C86339819 @default.
- W2892284745 hasConcept C86803240 @default.
- W2892284745 hasConcept C95444343 @default.
- W2892284745 hasConcept C96232424 @default.
- W2892284745 hasConceptScore W2892284745C104317684 @default.
- W2892284745 hasConceptScore W2892284745C11960822 @default.
- W2892284745 hasConceptScore W2892284745C121608353 @default.
- W2892284745 hasConceptScore W2892284745C126322002 @default.
- W2892284745 hasConceptScore W2892284745C153911025 @default.
- W2892284745 hasConceptScore W2892284745C196166836 @default.
- W2892284745 hasConceptScore W2892284745C202751555 @default.
- W2892284745 hasConceptScore W2892284745C203014093 @default.
- W2892284745 hasConceptScore W2892284745C2778923194 @default.
- W2892284745 hasConceptScore W2892284745C2779244956 @default.
- W2892284745 hasConceptScore W2892284745C2779723316 @default.
- W2892284745 hasConceptScore W2892284745C2780192828 @default.
- W2892284745 hasConceptScore W2892284745C2781184567 @default.
- W2892284745 hasConceptScore W2892284745C502942594 @default.
- W2892284745 hasConceptScore W2892284745C54355233 @default.
- W2892284745 hasConceptScore W2892284745C553184892 @default.
- W2892284745 hasConceptScore W2892284745C55493867 @default.
- W2892284745 hasConceptScore W2892284745C71924100 @default.
- W2892284745 hasConceptScore W2892284745C81885089 @default.
- W2892284745 hasConceptScore W2892284745C86339819 @default.
- W2892284745 hasConceptScore W2892284745C86803240 @default.
- W2892284745 hasConceptScore W2892284745C95444343 @default.
- W2892284745 hasConceptScore W2892284745C96232424 @default.
- W2892284745 hasLocation W28922847451 @default.
- W2892284745 hasOpenAccess W2892284745 @default.
- W2892284745 hasPrimaryLocation W28922847451 @default.
- W2892284745 hasRelatedWork W1968639238 @default.
- W2892284745 hasRelatedWork W2023649934 @default.
- W2892284745 hasRelatedWork W2068986710 @default.
- W2892284745 hasRelatedWork W2118642421 @default.
- W2892284745 hasRelatedWork W2148916294 @default.
- W2892284745 hasRelatedWork W2330432678 @default.
- W2892284745 hasRelatedWork W2403366312 @default.
- W2892284745 hasRelatedWork W2464386782 @default.
- W2892284745 hasRelatedWork W2520591314 @default.
- W2892284745 hasRelatedWork W2610198064 @default.
- W2892284745 isParatext "false" @default.
- W2892284745 isRetracted "false" @default.
- W2892284745 magId "2892284745" @default.
- W2892284745 workType "article" @default.