FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892284766> ?p ?o ?g. }

• W2892284766 endingPage "045033" @default.
• W2892284766 startingPage "045033" @default.
• W2892284766 abstract "Unfunctionalised few-layer graphene (FLG) refers to graphene materials and formulations which have low or no defects in the graphene sheet structure, thus enhancing their physico-chemical properties. However, the use of FLG and its derivatives in the biomedical field is not without risk to human health. It is largely accepted that the generation of reactive oxygen species and the consecutive inflammatory response is at the basis of its toxicity; nonetheless the signaling pathways triggered by FLG still need to be explored in detail. The present study was aimed at providing some elucidations on the specific molecular signaling induced by low doses of a well characterized FLG material in macrophages. Exposure to low doses of FLG resulted in no significant decrease of macrophage viability. Nevertheless, it elicited a marked oxidative stress. The latter triggered significant inflammatory responses, increasing Tumor Necrosis Factor-alpha (TNF-α) and Interleukin-6 (IL-6) secretion as well as nitric oxide (NO) production, leading to autophagy via endoplasmic reticulum (ER) stress. Indeed, exposure to FLG in the presence of 4-phenylbutyrate (4-PBA) and N-acetyl-L-cysteine (NAC), inhibitors of ER stress and oxidative stress, respectively, decreased ER stress, autophagy, oxidative stress and inflammation. Interestingly, graphene exposure did not induce Interleukin-1Beta (IL-1β) and Interleukin-18 (IL-18) secretion, which are indicators of inflammasome activation. Pre-treatment with 3-Methyladenine (3-MA), an autophagy inhibitor, actually suppressed the autophagy activation triggered by graphene exposure, but leaded to inflammasome activation. Our work highlight for the first time for this type graphene an interplay between oxidative stress and ER stress-mediated autophagy. It also suggests that such a pathway could protect the cells from exaggerated inflammation. This study underlines the importance of having a clear overview on the mechanism behind the interaction between FLG and cells, especially when graphene is used for the development of novel biomedical materials." @default.
• W2892284766 created "2018-09-27" @default.
• W2892284766 creator A5006288004 @default.
• W2892284766 creator A5011976970 @default.
• W2892284766 creator A5030283020 @default.
• W2892284766 creator A5076630519 @default.
• W2892284766 creator A5091232075 @default.
• W2892284766 date "2018-09-25" @default.
• W2892284766 modified "2023-10-01" @default.
• W2892284766 title "Interplay between oxidative stress and endoplasmic reticulum stress mediated- autophagy in unfunctionalised few-layer graphene-exposed macrophages" @default.
• W2892284766 cites W1561041814 @default.
• W2892284766 cites W1697178647 @default.
• W2892284766 cites W1980748692 @default.
• W2892284766 cites W1984477246 @default.
• W2892284766 cites W1989982033 @default.
• W2892284766 cites W1991605413 @default.
• W2892284766 cites W1991859775 @default.
• W2892284766 cites W1992177385 @default.
• W2892284766 cites W2008290409 @default.
• W2892284766 cites W2010226025 @default.
• W2892284766 cites W2010971702 @default.
• W2892284766 cites W2011977247 @default.
• W2892284766 cites W2014063358 @default.
• W2892284766 cites W2015706810 @default.
• W2892284766 cites W2019383068 @default.
• W2892284766 cites W2020442486 @default.
• W2892284766 cites W2022050193 @default.
• W2892284766 cites W2028536701 @default.
• W2892284766 cites W2048294524 @default.
• W2892284766 cites W2052092440 @default.
• W2892284766 cites W2055224823 @default.
• W2892284766 cites W2059952390 @default.
• W2892284766 cites W2065911566 @default.
• W2892284766 cites W2072932217 @default.
• W2892284766 cites W2074880343 @default.
• W2892284766 cites W2076062022 @default.
• W2892284766 cites W2077637800 @default.
• W2892284766 cites W2079165562 @default.
• W2892284766 cites W2083278580 @default.
• W2892284766 cites W2092219520 @default.
• W2892284766 cites W2101353938 @default.
• W2892284766 cites W2106749088 @default.
• W2892284766 cites W2125612486 @default.
• W2892284766 cites W2126934395 @default.
• W2892284766 cites W2126941192 @default.
• W2892284766 cites W2137444266 @default.
• W2892284766 cites W2144905693 @default.
• W2892284766 cites W2149766325 @default.
• W2892284766 cites W2152999291 @default.
• W2892284766 cites W2162610636 @default.
• W2892284766 cites W2220904281 @default.
• W2892284766 cites W2238318903 @default.
• W2892284766 cites W2252401283 @default.
• W2892284766 cites W2276121356 @default.
• W2892284766 cites W2281371963 @default.
• W2892284766 cites W2340436312 @default.
• W2892284766 cites W2345784910 @default.
• W2892284766 cites W2434658048 @default.
• W2892284766 cites W2563585318 @default.
• W2892284766 cites W2592639131 @default.
• W2892284766 cites W2744123648 @default.
• W2892284766 cites W2752862273 @default.
• W2892284766 cites W2753610536 @default.
• W2892284766 cites W4255250780 @default.
• W2892284766 cites W66711298 @default.
• W2892284766 doi "https://doi.org/10.1088/2053-1583/aadf45" @default.
• W2892284766 hasPublicationYear "2018" @default.
• W2892284766 type Work @default.
• W2892284766 sameAs 2892284766 @default.
• W2892284766 citedByCount "15" @default.
• W2892284766 countsByYear W28922847662019 @default.
• W2892284766 countsByYear W28922847662020 @default.
• W2892284766 countsByYear W28922847662021 @default.
• W2892284766 countsByYear W28922847662022 @default.
• W2892284766 countsByYear W28922847662023 @default.
• W2892284766 crossrefType "journal-article" @default.
• W2892284766 hasAuthorship W2892284766A5006288004 @default.
• W2892284766 hasAuthorship W2892284766A5011976970 @default.
• W2892284766 hasAuthorship W2892284766A5030283020 @default.
• W2892284766 hasAuthorship W2892284766A5076630519 @default.
• W2892284766 hasAuthorship W2892284766A5091232075 @default.
• W2892284766 hasConcept C134018914 @default.
• W2892284766 hasConcept C139447449 @default.
• W2892284766 hasConcept C158617107 @default.
• W2892284766 hasConcept C164027704 @default.
• W2892284766 hasConcept C17991360 @default.
• W2892284766 hasConcept C185592680 @default.
• W2892284766 hasConcept C190283241 @default.
• W2892284766 hasConcept C203014093 @default.
• W2892284766 hasConcept C203522944 @default.
• W2892284766 hasConcept C2776151105 @default.
• W2892284766 hasConcept C2776914184 @default.
• W2892284766 hasConcept C2777209026 @default.
• W2892284766 hasConcept C48349386 @default.
• W2892284766 hasConcept C49039625 @default.
• W2892284766 hasConcept C519581460 @default.
• W2892284766 hasConcept C55493867 @default.
• W2892284766 hasConcept C71924100 @default.

• next