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- W2892286102 abstract "The tolerability of adjuvant chemotherapy in esophageal cancer is unclear.This was a phase II trial of adjuvant paclitaxel in patients with esophageal cancer after trimodality treatment. Patients with residual viable tumor after resection were eligible for study inclusion. Treatment was 80 mg/m2 paclitaxel intravenously on days 1, 8, and 15 every 28 days for total of two cycles. The primary objective was to determine whether 75% or more of the patients would tolerate 240 mg/m2 or more of paclitaxel, which corresponded to 50% or more of the total planned dose.Eleven out of the 12 enrolled patients (92%, 95% confidence interval (CI)=62-100%) were able to complete at least 50% of the planned paclitaxel dose. Median progression-free survival was 7 months (95% CI=2-28 months). Median overall survival was 28 months (95% CI=12-36 months). Only one patient experienced a grade 4 adverse event.Screening patients with esophageal cancer after trimodality treatment might improve completion of adjuvant trials." @default.
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- W2892286102 date "2018-09-01" @default.
- W2892286102 modified "2023-09-25" @default.
- W2892286102 title "Screening Patients with Esophageal Cancer to Determine Eligibility for Adjuvant Treatment Trials" @default.
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- W2892286102 doi "https://doi.org/10.21873/anticanres.12849" @default.
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