Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892288910> ?p ?o ?g. }
- W2892288910 endingPage "e2006519" @default.
- W2892288910 startingPage "e2006519" @default.
- W2892288910 abstract "Copper (Cu) has emerged as an important modifier of body lipid metabolism. However, how Cu contributes to the physiology of fat cells remains largely unknown. We found that adipocytes require Cu to establish a balance between main metabolic fuels. Differentiating adipocytes increase their Cu uptake along with the ATP7A-dependent transport of Cu into the secretory pathway to activate a highly up-regulated amino-oxidase copper-containing 3 (AOC3)/semicarbazide-sensitive amine oxidase (SSAO); in vivo, the activity of SSAO depends on the organism’s Cu status. Activated SSAO oppositely regulates uptake of glucose and long-chain fatty acids and remodels the cellular proteome to coordinate changes in fuel availability and related downstream processes, such as glycolysis, de novo lipogenesis, and sphingomyelin/ceramide synthesis. The loss of SSAO-dependent regulation due to Cu deficiency, limited Cu transport to the secretory pathway, or SSAO inactivation shifts metabolism towards lipid-dependent pathways and results in adipocyte hypertrophy and fat accumulation. The results establish a role for Cu homeostasis in adipocyte metabolism and identify SSAO as a regulator of energy utilization processes in adipocytes." @default.
- W2892288910 created "2018-09-27" @default.
- W2892288910 creator A5007640637 @default.
- W2892288910 creator A5019536936 @default.
- W2892288910 creator A5021817779 @default.
- W2892288910 creator A5022491794 @default.
- W2892288910 creator A5043042092 @default.
- W2892288910 creator A5043625186 @default.
- W2892288910 creator A5046814999 @default.
- W2892288910 creator A5048613121 @default.
- W2892288910 creator A5067816988 @default.
- W2892288910 creator A5079179187 @default.
- W2892288910 date "2018-09-10" @default.
- W2892288910 modified "2023-10-18" @default.
- W2892288910 title "Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes" @default.
- W2892288910 cites W1787999554 @default.
- W2892288910 cites W1901815720 @default.
- W2892288910 cites W1967454801 @default.
- W2892288910 cites W1973067127 @default.
- W2892288910 cites W1974267599 @default.
- W2892288910 cites W1976313024 @default.
- W2892288910 cites W1979261983 @default.
- W2892288910 cites W1981089957 @default.
- W2892288910 cites W1984999019 @default.
- W2892288910 cites W1987555708 @default.
- W2892288910 cites W1990371612 @default.
- W2892288910 cites W1990403218 @default.
- W2892288910 cites W1992561979 @default.
- W2892288910 cites W2011442035 @default.
- W2892288910 cites W2012374994 @default.
- W2892288910 cites W2015673383 @default.
- W2892288910 cites W2015968822 @default.
- W2892288910 cites W2016262934 @default.
- W2892288910 cites W2028168243 @default.
- W2892288910 cites W2043161246 @default.
- W2892288910 cites W2043281805 @default.
- W2892288910 cites W2045052883 @default.
- W2892288910 cites W2045928515 @default.
- W2892288910 cites W2050577046 @default.
- W2892288910 cites W2060219393 @default.
- W2892288910 cites W2067265529 @default.
- W2892288910 cites W2075873583 @default.
- W2892288910 cites W2085453780 @default.
- W2892288910 cites W2103180882 @default.
- W2892288910 cites W2114978842 @default.
- W2892288910 cites W2115488718 @default.
- W2892288910 cites W2125268191 @default.
- W2892288910 cites W2125747346 @default.
- W2892288910 cites W2128319960 @default.
- W2892288910 cites W2156615522 @default.
- W2892288910 cites W2156690149 @default.
- W2892288910 cites W2163694606 @default.
- W2892288910 cites W2165421124 @default.
- W2892288910 cites W2166946563 @default.
- W2892288910 cites W2168526937 @default.
- W2892288910 cites W2228937870 @default.
- W2892288910 cites W2271559568 @default.
- W2892288910 cites W2297411548 @default.
- W2892288910 cites W2396811662 @default.
- W2892288910 cites W2408318651 @default.
- W2892288910 cites W2419048965 @default.
- W2892288910 cites W2760279858 @default.
- W2892288910 cites W4214596293 @default.
- W2892288910 cites W4231179697 @default.
- W2892288910 cites W140599224 @default.
- W2892288910 doi "https://doi.org/10.1371/journal.pbio.2006519" @default.
- W2892288910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6130853" @default.
- W2892288910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30199530" @default.
- W2892288910 hasPublicationYear "2018" @default.
- W2892288910 type Work @default.
- W2892288910 sameAs 2892288910 @default.
- W2892288910 citedByCount "40" @default.
- W2892288910 countsByYear W28922889102019 @default.
- W2892288910 countsByYear W28922889102020 @default.
- W2892288910 countsByYear W28922889102021 @default.
- W2892288910 countsByYear W28922889102022 @default.
- W2892288910 countsByYear W28922889102023 @default.
- W2892288910 crossrefType "journal-article" @default.
- W2892288910 hasAuthorship W2892288910A5007640637 @default.
- W2892288910 hasAuthorship W2892288910A5019536936 @default.
- W2892288910 hasAuthorship W2892288910A5021817779 @default.
- W2892288910 hasAuthorship W2892288910A5022491794 @default.
- W2892288910 hasAuthorship W2892288910A5043042092 @default.
- W2892288910 hasAuthorship W2892288910A5043625186 @default.
- W2892288910 hasAuthorship W2892288910A5046814999 @default.
- W2892288910 hasAuthorship W2892288910A5048613121 @default.
- W2892288910 hasAuthorship W2892288910A5067816988 @default.
- W2892288910 hasAuthorship W2892288910A5079179187 @default.
- W2892288910 hasBestOaLocation W28922889101 @default.
- W2892288910 hasConcept C141359234 @default.
- W2892288910 hasConcept C171089720 @default.
- W2892288910 hasConcept C190283241 @default.
- W2892288910 hasConcept C203522944 @default.
- W2892288910 hasConcept C25095133 @default.
- W2892288910 hasConcept C2776175234 @default.
- W2892288910 hasConcept C2777851122 @default.
- W2892288910 hasConcept C4733338 @default.
- W2892288910 hasConcept C55493867 @default.