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• W2892291239 abstract "Summary Our study aimed to clarify the correlation between miR‐1247‐5p expression and clinicopathological parameters and survival of patients with breast cancer ( BC ). We evaluated the expression level of miR‐1247‐5p in 224 formalin‐fixed, paraffin‐embedded specimens (112 BC and matched cancer free tissues) by quantitative real‐time reverse transcriptase polymerase chain reaction ( qRT ‐ PCR ). miR‐1247‐5p expression in BC tissues was found to be decreased compared with matched normal tissues ( P < 0.01). Additionally, low miR‐1247‐5p expression in BC tissues was significantly associated with the advanced TNM stage ( P = 0.007), lymph node metastasis ( P = 0.015), poorer pathological differentiation ( P = 0.005) and molecular subtype ( P = 0.027). The patients in the low miR‐1247‐5p group had a shorter disease‐free survival and overall survival than those in the high miR‐1247‐5p group ( P < 0.01). Furthermore, the univariate and the multivariate analyses showed that miR‐1247‐5p expression was an independent predictor of overall survival ( P < 0.01). Our study showed that miR‐1247‐5p was related to the biological behaviour of breast tumour and prognosis of patients with BC. miR‐1247‐5p could be a novel tumour suppressor and act as a potential biomarker and therapeutic agent for breast carcinoma." @default.
• W2892291239 created "2018-09-27" @default.
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• W2892291239 date "2018-08-01" @default.
• W2892291239 modified "2023-10-06" @default.
• W2892291239 title "Association of miR-1247-5p expression with clinicopathological parameters and prognosis in breast cancer" @default.
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• W2892291239 doi "https://doi.org/10.1111/iep.12287" @default.
• W2892291239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6157300" @default.
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