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- W2892292123 abstract "Lactobacillus species are widelyaccepted as beneficial bacteria of the human microbiota1-8.Lactobacilli spp. are well documented to inhibit pathogens byproduction and secretion of hydrogen peroxide (H2O2), organicacids, and/or proteinaceous bacteriocins into their environment.Most research attributes bactericidal activity of cell freesupernatant (CFS) to H2O2 and/or lactic acid. Here, I demonstratethat CFS from a clinical isolate of Lactobacillus crispatuscontains a molecule(s) that inhibits uropathogenic Escherichia coli(UPEC) colony formation independently of H2O2 and organic acids.Physiologic concentrations of H2O2 and organic acids produced by L.crispatus do not inhibit UPEC colony formation. Incubation of UPECwith L. crispatus CFS has a bactericidal effect on UPEC that beginsat about 4 hours and results in undetectable CFUs by 16 hours,apparently the result of severe plasmolysis. Bactericidal activityof this CFS is effective against some Gram-negative andGram-positive species including multidrug resistant (MDR) E. coli.The broad-spectrum activity shows CFS may have applicability asfuture therapeutic for treatment of various bacterial infectionsincluding MDR infections. The active molecule(s)present in CFS is stable over a wide temperature range and can bestored for at least 3 months while retaining full bactericidalactivity. The active molecule(s) is sensitive to dilution andincreased salt concentrations. The active molecule(s) from CFS canbe isolated via organic extraction. Based on the extractionprofile, the molecule is predicted to be a dipolar organicmolecule(s). The majority of proteins and tri-peptides are removedduring organic extraction yet extracts retain full bactericidalactivity. I conclude that L. crispatus produces a very stablepotentially novel dipolar, organic molecule with broad-spectrumactivity that is concentration-dependent and salt-sensitive, andwhich results in plasmolytic activity against its target. Isolationand identification of this molecule(s) could lead to application asa decontaminant or therapeutic." @default.
- W2892292123 created "2018-09-27" @default.
- W2892292123 creator A5020283117 @default.
- W2892292123 date "2017-01-01" @default.
- W2892292123 modified "2023-09-26" @default.
- W2892292123 title "Characterization of Inhibitory Molecules Produced by Lactobacillus Crispatus" @default.
- W2892292123 hasPublicationYear "2017" @default.
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