FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892298192> ?p ?o ?g. }

• W2892298192 endingPage "156" @default.
• W2892298192 startingPage "145" @default.
• W2892298192 abstract "Multipotent mesenchymal stem cells (MSCs) maintain the ability to differentiate into adipogenic, chondrogenic, or osteogenic cell lineages. There is increasing concern that exposure to environmental agents such as aryl hydrocarbon receptor (AhR) ligands, may perturb the osteogenic pathways responsible for normal bone formation. The objective of the current study was to evaluate the potential of the prototypic AhR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to disrupt osteogenic differentiation of human bone-derived MSCs (hBMSCs) in vitro. Primary hBMSCs from three donors were exposed to 10 nM TCDD and differentiation was interrogated using select histological, biochemical, and transcriptional markers of osteogenesis. Exposure to 10 nM TCDD resulted in an overall consistent attenuation of alkaline phosphatase (ALP) activity and matrix mineralization at terminal stages of differentiation in primary hBMSCs. At the transcriptional level, the transcriptional regulator DLX5 and additional osteogenic markers (ALP, OPN, and IBSP) displayed attenuated expression; conversely, FGF9 and FGF18 were consistently upregulated in each donor. Expression of stem cell potency markers SOX2, NANOG, and SALL4 decreased in the osteogenic controls, whereas expression in TCDD-treated cells resembled that of undifferentiated cells. Coexposure with the AhR antagonist GNF351 blocked TCDD-mediated attenuation of matrix mineralization, and either fully or partially rescued expression of genes associated with osteogenic regulation, extracellular matrix, and/or maintenance of multipotency. Thus, experimental evidence from this study suggests that AhR transactivation likely attenuates osteoblast differentiation in multipotent hBMSCs. This study also underscores the use of primary human MSCs to evaluate osteoinductive or osteotoxic potential of chemical and pharmacologic agents in vitro." @default.
• W2892298192 created "2018-09-27" @default.
• W2892298192 creator A5005718258 @default.
• W2892298192 creator A5010927797 @default.
• W2892298192 creator A5044261921 @default.
• W2892298192 creator A5033908193 @default.
• W2892298192 date "2018-09-07" @default.
• W2892298192 modified "2023-10-16" @default.
• W2892298192 title "Evidence for Aryl hydrocarbon Receptor-Mediated Inhibition of Osteoblast Differentiation in Human Mesenchymal Stem Cells" @default.
• W2892298192 cites W1538954095 @default.
• W2892298192 cites W1955663152 @default.
• W2892298192 cites W1963807298 @default.
• W2892298192 cites W1967726208 @default.
• W2892298192 cites W1978228345 @default.
• W2892298192 cites W1978726115 @default.
• W2892298192 cites W1979796931 @default.
• W2892298192 cites W1985716862 @default.
• W2892298192 cites W1988161053 @default.
• W2892298192 cites W1991676563 @default.
• W2892298192 cites W1995221916 @default.
• W2892298192 cites W1995554650 @default.
• W2892298192 cites W2000609551 @default.
• W2892298192 cites W2002667904 @default.
• W2892298192 cites W2009325251 @default.
• W2892298192 cites W2011330291 @default.
• W2892298192 cites W2016625153 @default.
• W2892298192 cites W2016629712 @default.
• W2892298192 cites W2021231315 @default.
• W2892298192 cites W2035462789 @default.
• W2892298192 cites W2037237546 @default.
• W2892298192 cites W2037728061 @default.
• W2892298192 cites W2040568539 @default.
• W2892298192 cites W2041112903 @default.
• W2892298192 cites W2042493065 @default.
• W2892298192 cites W2044607889 @default.
• W2892298192 cites W2050152863 @default.
• W2892298192 cites W2053288021 @default.
• W2892298192 cites W2057399298 @default.
• W2892298192 cites W2057888154 @default.
• W2892298192 cites W2057900202 @default.
• W2892298192 cites W2062133273 @default.
• W2892298192 cites W2074266669 @default.
• W2892298192 cites W2081989528 @default.
• W2892298192 cites W2083339509 @default.
• W2892298192 cites W2085042732 @default.
• W2892298192 cites W2092288031 @default.
• W2892298192 cites W2094770462 @default.
• W2892298192 cites W2095030054 @default.
• W2892298192 cites W2097091732 @default.
• W2892298192 cites W2097256926 @default.
• W2892298192 cites W2101027724 @default.
• W2892298192 cites W2114434551 @default.
• W2892298192 cites W2117214043 @default.
• W2892298192 cites W2125166061 @default.
• W2892298192 cites W2140691687 @default.
• W2892298192 cites W2143847855 @default.
• W2892298192 cites W2144892086 @default.
• W2892298192 cites W2147881974 @default.
• W2892298192 cites W2314408623 @default.
• W2892298192 cites W2316879128 @default.
• W2892298192 cites W2378376721 @default.
• W2892298192 cites W2397182876 @default.
• W2892298192 cites W2470365122 @default.
• W2892298192 cites W2553281039 @default.
• W2892298192 cites W2593809367 @default.
• W2892298192 cites W2730267944 @default.
• W2892298192 cites W2800079070 @default.
• W2892298192 cites W2807938753 @default.
• W2892298192 doi "https://doi.org/10.1093/toxsci/kfy225" @default.
• W2892298192 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6317429" @default.
• W2892298192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30203000" @default.
• W2892298192 hasPublicationYear "2018" @default.
• W2892298192 type Work @default.
• W2892298192 sameAs 2892298192 @default.
• W2892298192 citedByCount "27" @default.
• W2892298192 countsByYear W28922981922019 @default.
• W2892298192 countsByYear W28922981922020 @default.
• W2892298192 countsByYear W28922981922021 @default.
• W2892298192 countsByYear W28922981922022 @default.
• W2892298192 countsByYear W28922981922023 @default.
• W2892298192 crossrefType "journal-article" @default.
• W2892298192 hasAuthorship W2892298192A5005718258 @default.
• W2892298192 hasAuthorship W2892298192A5010927797 @default.
• W2892298192 hasAuthorship W2892298192A5033908193 @default.
• W2892298192 hasAuthorship W2892298192A5044261921 @default.
• W2892298192 hasBestOaLocation W28922981921 @default.
• W2892298192 hasConcept C104317684 @default.
• W2892298192 hasConcept C122927707 @default.
• W2892298192 hasConcept C148738053 @default.
• W2892298192 hasConcept C160160445 @default.
• W2892298192 hasConcept C181199279 @default.
• W2892298192 hasConcept C185592680 @default.
• W2892298192 hasConcept C198826908 @default.
• W2892298192 hasConcept C202751555 @default.
• W2892298192 hasConcept C2776363554 @default.
• W2892298192 hasConcept C2777933648 @default.
• W2892298192 hasConcept C2778260815 @default.
• W2892298192 hasConcept C28328180 @default.

• next