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• W2892301963 abstract "SUMMARY Gene expression is regulated by nuclear accessibility of transcription factors controlled by transport receptors and competitive inhibitors. Multiple karyopherin-βs (Kap-βs) facilitate nuclear import of yeast TATA-binding protein (yTBP). However, only Kap114p suppresses temperature-sensitive yTBP mutations, suggesting Kap114p executes undefined non-transport functions. We show that yTBP preferably binds Kap114p with an affinity three orders of magnitude higher than other Kap-βs facilitating yTBP nuclear import. Our crystal structure of Kap114p reveals an extensively negatively-charged concave surface, accounting for high-affinity basic-protein binding. Furthermore, we biochemically demonstrate that two intra-HEAT-repeat inserts act as regulatory TBP-binding domains carried by TBP-associated factor 1 (TAF1-TAND), suppressing binding of yTBP with DNA and the transcription factor IIA. Remarkably, dual-knockout of Kap114 and TAF1-TAND in yeast synergistically suppresses cell growth. Our study reveals that Kap114p has a dual function that modulates the nuclear localization and activity of yTBP, illuminating how the nuclear transport machinery regulates yTBP-mediated transcription." @default.
• W2892301963 created "2018-09-27" @default.
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• W2892301963 date "2018-09-07" @default.
• W2892301963 modified "2023-09-24" @default.
• W2892301963 title "Karyopherin Kap114p regulates TATA-binding protein-mediated transcription" @default.
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• W2892301963 doi "https://doi.org/10.1101/411223" @default.
• W2892301963 hasPublicationYear "2018" @default.
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