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• W2892307514 endingPage "2730" @default.
• W2892307514 startingPage "2730" @default.
• W2892307514 abstract "Right ventricular failure (RVF) remains the leading cause of death in pulmonary arterial hypertension (PAH). We investigated the transcriptomic signature of RVF in hemodynamically well-phenotyped monocrotaline (MCT)-treated, male, Sprague-Dawley rats with severe PAH and decompensated RVF (increased right ventricular (RV) end diastolic volume (EDV), decreased cardiac output (CO), tricuspid annular plane systolic excursion (TAPSE) and ventricular-arterial decoupling). RNA sequencing revealed 2547 differentially regulated transcripts in MCT-RVF RVs. Multiple enriched gene ontology (GO) terms converged on mitochondria/metabolism, fibrosis, inflammation, and angiogenesis. The mitochondrial transcriptomic pathway is the most affected in RVF, with 413 dysregulated genes. Downregulated genes included TFAM (−0.45-fold), suggesting impaired mitochondrial biogenesis, CYP2E1 (−3.8-fold), a monooxygenase which when downregulated increases oxidative stress, dehydrogenase/reductase 7C (DHRS7C) (−2.8-fold), consistent with excessive autonomic activation, and polypeptide N-acetyl-galactose-aminyl-transferase 13 (GALNT13), a known pulmonary hypertension (PH) biomarker (−2.7-fold). The most up-regulated gene encodes Periostin (POSTN; 4.5-fold), a matricellular protein relevant to fibrosis. Other dysregulated genes relevant to fibrosis include latent-transforming growth factor beta-binding protein 2 (LTBP2), thrombospondin4 (THBS4). We also identified one dysregulated gene relevant to all disordered transcriptomic pathways, ANNEXIN A1. This anti-inflammatory, phospholipid-binding mediator, is a putative target for therapy in RVF-PAH. Comparison of expression profiles in the MCT-RV with published microarray data from the RV of pulmonary artery-banded mice and humans with bone morphogenetic protein receptor type 2 (BMPR2)-mutations PAH reveals substantial conservation of gene dysregulation, which may facilitate clinical translation of preclinical therapeutic and biomarkers studies. Transcriptomics reveals the molecular fingerprint of RVF to be heavily characterized by mitochondrial dysfunction, fibrosis and inflammation." @default.
• W2892307514 created "2018-09-27" @default.
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• W2892307514 date "2018-09-12" @default.
• W2892307514 modified "2023-09-28" @default.
• W2892307514 title "Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities" @default.
• W2892307514 cites W1573852374 @default.
• W2892307514 cites W1843694384 @default.
• W2892307514 cites W1869491884 @default.
• W2892307514 cites W189074344 @default.
• W2892307514 cites W1934555047 @default.
• W2892307514 cites W1944669821 @default.
• W2892307514 cites W1967922846 @default.
• W2892307514 cites W1968327956 @default.
• W2892307514 cites W1977074396 @default.
• W2892307514 cites W1977216656 @default.
• W2892307514 cites W1978132227 @default.
• W2892307514 cites W1988191641 @default.
• W2892307514 cites W1988739272 @default.
• W2892307514 cites W1990875061 @default.
• W2892307514 cites W2004098988 @default.
• W2892307514 cites W2025266368 @default.
• W2892307514 cites W2028813118 @default.
• W2892307514 cites W2035045924 @default.
• W2892307514 cites W2035371717 @default.
• W2892307514 cites W2036439732 @default.
• W2892307514 cites W2039226089 @default.
• W2892307514 cites W2045037837 @default.
• W2892307514 cites W2045857583 @default.
• W2892307514 cites W2058657865 @default.
• W2892307514 cites W2066143342 @default.
• W2892307514 cites W2067413933 @default.
• W2892307514 cites W2073165828 @default.
• W2892307514 cites W2075789827 @default.
• W2892307514 cites W2077418333 @default.
• W2892307514 cites W2077633549 @default.
• W2892307514 cites W2100320418 @default.
• W2892307514 cites W2107882829 @default.
• W2892307514 cites W2108095498 @default.
• W2892307514 cites W2113580488 @default.
• W2892307514 cites W2114150480 @default.
• W2892307514 cites W2116087813 @default.
• W2892307514 cites W2124502562 @default.
• W2892307514 cites W2124549031 @default.
• W2892307514 cites W2130290719 @default.
• W2892307514 cites W2130661187 @default.
• W2892307514 cites W2134780421 @default.
• W2892307514 cites W2135341547 @default.
• W2892307514 cites W2139944408 @default.
• W2892307514 cites W2145051756 @default.
• W2892307514 cites W2146966841 @default.
• W2892307514 cites W2155720896 @default.
• W2892307514 cites W2158217645 @default.
• W2892307514 cites W2161340566 @default.
• W2892307514 cites W2161561494 @default.
• W2892307514 cites W2184332638 @default.
• W2892307514 cites W2195395987 @default.
• W2892307514 cites W2202999240 @default.
• W2892307514 cites W2217965949 @default.
• W2892307514 cites W2239766406 @default.
• W2892307514 cites W2346810793 @default.
• W2892307514 cites W2465642439 @default.
• W2892307514 cites W2547368870 @default.
• W2892307514 cites W2591928386 @default.
• W2892307514 cites W2603460820 @default.
• W2892307514 cites W2607413744 @default.
• W2892307514 cites W2735815044 @default.
• W2892307514 cites W2753449525 @default.
• W2892307514 cites W2766674089 @default.
• W2892307514 cites W2769705721 @default.
• W2892307514 cites W2781701648 @default.
• W2892307514 cites W2785660664 @default.
• W2892307514 cites W2789769541 @default.
• W2892307514 cites W2799900665 @default.
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• W2892307514 doi "https://doi.org/10.3390/ijms19092730" @default.
• W2892307514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6164263" @default.
• W2892307514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30213070" @default.
• W2892307514 hasPublicationYear "2018" @default.
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