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- W2892310806 abstract "In addition to its role in ribosome biogenesis, ribosomal protein S3 (RPS3), a component of the 40S ribosomal subunit, has been suggested to possess several extraribosomal functions, including an apoptotic function. In this study, we demonstrated that in the mouse brain, the protein levels of RPS3 were altered by the degree of nutritional starvation and correlated with neuronal apoptosis. After endurable short-term starvation, the apoptotic function of RPS3 was suppressed by Akt activation and Akt-mediated T70 phosphorylation, whereas after prolonged starvation, the protein levels of RPS3 notably increased, and abundant neuronal death occurred. These events coincided with ubiquitination and subsequent degradation of RPS3, controlled by HSP70 and the cochaperone E3 ligase: carboxy terminus of heat shock protein 70-interacting protein (CHIP). Thus, our study points to an extraribosomal role of RPS3 in balancing neuronal survival or death depending on the degree of starvation through CHIP-mediated polyubiquitination and degradation." @default.
- W2892310806 created "2018-09-27" @default.
- W2892310806 creator A5002964544 @default.
- W2892310806 creator A5010412155 @default.
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- W2892310806 date "2018-09-12" @default.
- W2892310806 modified "2023-09-28" @default.
- W2892310806 title "Chaperone-E3 Ligase Complex HSP70-CHIP Mediates Ubiquitination of Ribosomal Protein S3" @default.
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- W2892310806 doi "https://doi.org/10.3390/ijms19092723" @default.
- W2892310806 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6163665" @default.
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