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- W2892313784 abstract "Abstract Statins, inhibitors of 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase, are a well‐known class of drug with beneficial therapeutic effects in cardiovascular disease and lipid disorders and have potential use against cancer. However, the bioavailability of statins is hampered due to low aqueous solubility and rapid metabolism. To improve pharmacokinetic profiles of statins, development of drug delivery systems is promising. Hence, the use of liposomes for selective delivery of statins to a selected site or for bioavailability enhancement is an effective strategy to increase statin therapeutic effects. Moreover, liposomal delivery can reduce the required dose of statins especially in terms of antitumor effects. Liposomes, because of their unique properties and biphasic and amphiphilic nature, have attracted much interest and can be considered as a suitable choice for delivery of both hydrophilic and lipophilic statins. In this review article, we focus on liposomes and evaluate the effects of different liposomal delivery systems, based on differences in size, phospholipid composition, circulation half‐life, and cholesterol content, on statin function." @default.
- W2892313784 created "2018-09-27" @default.
- W2892313784 creator A5023255400 @default.
- W2892313784 creator A5031560022 @default.
- W2892313784 creator A5060364685 @default.
- W2892313784 creator A5061268454 @default.
- W2892313784 date "2018-09-10" @default.
- W2892313784 modified "2023-09-26" @default.
- W2892313784 title "Liposomal nanocarriers for statins: A pharmacokinetic and pharmacodynamics appraisal" @default.
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- W2892313784 doi "https://doi.org/10.1002/jcp.27121" @default.
- W2892313784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30203471" @default.
- W2892313784 hasPublicationYear "2018" @default.
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