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• W2892313953 endingPage "234" @default.
• W2892313953 startingPage "217" @default.
• W2892313953 abstract "Ovulation is the appropriately timed release of a mature developmental competent oocyte from the ovary into the oviduct where fertilization occurs. Ovulation is triggered by the gonadotropin surge and regulated by intrafollicular paracrine factors from the theca, mural and cumulus granulosa cells, and the oocyte itself. This chapter focuses on the molecular processes that commence after the LH surge and culminate with release of the oocyte. These mechanisms include intracellular signaling, gene regulation, and protein activation in each of the distinct compartments of the ovarian follicle. The result is the induction of cumulus expansion, proteolysis, angiogenesis, inflammation and immune cell infiltration, and muscle contraction which are each required to trigger follicular rupture. Thus, the process of ovulation involves multiple cell types within the follicle cooperating to successfully release the cumulus-oocyte complex, in synchrony with luteinization and oocyte maturation. These complex intercellular communication networks and the essential ovulatory genes have been well-defined in animal models and are highly conserved in primates including humans. Clinically, anovulation is a common cause of female infertility and ovulation can be prevented by use of hormonal contraceptives." @default.
• W2892313953 created "2018-09-27" @default.
• W2892313953 creator A5007839058 @default.
• W2892313953 creator A5048084503 @default.
• W2892313953 date "2019-01-01" @default.
• W2892313953 modified "2023-10-18" @default.
• W2892313953 title "Ovulation: The Coordination of Intrafollicular Networks to Ensure Oocyte Release" @default.
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