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- W2892314692 endingPage "96" @default.
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- W2892314692 abstract "Older patients are generally not included in Phase 1 clinical trials despite being the population group who use the largest number of prescription medicines. Physiologically based pharmacokinetic (PBPK) modelling provides an understanding of the absorption and disposition of drugs in older patients. In this review, PBPK models used for the prediction of absorption and exposure of drugs after parenteral, oral and transdermal administration are discussed. Comparisons between predicted drug pharmacokinetics (PK) and observed PK are presented to illustrate the accuracy of the predictions by the PBPK models and their potential use in informing clinical trial design and dosage adjustments in older patients. In addition, a case of PBPK modelling of a bioequivalence study on two controlled release products is described, where PBPK predictions reproduced the study showing bioequivalence in healthy volunteers but not in older subjects with achlorhydria, indicating further utility in prospectively identifying challenges in bioequivalence studies." @default.
- W2892314692 created "2018-09-27" @default.
- W2892314692 creator A5002054470 @default.
- W2892314692 creator A5002332035 @default.
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- W2892314692 creator A5051566641 @default.
- W2892314692 creator A5054966624 @default.
- W2892314692 creator A5070835056 @default.
- W2892314692 date "2018-10-01" @default.
- W2892314692 modified "2023-10-12" @default.
- W2892314692 title "Physiologically based pharmacokinetic modelling to guide drug delivery in older people" @default.
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