FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892317792> ?p ?o ?g. }

• W2892317792 endingPage "1552.e10" @default.
• W2892317792 startingPage "1536" @default.
• W2892317792 abstract "A successful immune response is critically necessary to eradicate infectious challenges and prevent dissemination of the infection in the host. However, if inflammation is not limited and becomes generalized, it can result in the constellation of signs and symptoms of a systemic inflammatory response syndrome (SIRS). If the infection is not contained, the spread of the pathogen from its local origin through the blood may result in systemic endothelial activation and precipitate sepsis, severe sepsis, and septic shock. Progression of sepsis to shock may lead to multiple organ dysfunction syndrome (MODS) and ultimately death.Host immunity is divided into innate and adaptive immune systems for purposes of discussion and teaching but there is a great deal of interaction between the two systems. Innate immunity is rapid, largely nonspecific, and composed of barriers, phagocytic cells, the complement system, and other soluble components of inflammation. After breech of a barrier, cellular elements of the innate immune response are the first line of defense against the development and progression of infection. Adaptive immunity, which is antigen specific, is long lived, and often takes several days to develop, provides immunologic specificity and memory. These systems work together to protect the host from pathogenic challenge but may also precipitate host injury through aberrant responses. The outcome of infection is dependent on at least four major factors: (1) the pathogen, (2) the pathogen load, (3) the site of infection, and (4) the host response. Less is known about the host response in neonates compared with adults for a number of reasons, the principal one being a highly variable definition of disease.Our understanding of the pathophysiology of sepsis is largely from investigations in adult populations, including both humans and animals. There is clear evidence from both preclinical models of sepsis and humans that neonates manifest different host immune responses as compared with adults.1, 2, 3, 4 Even in comparison with children, neonates manifest a unique host immune response to septic shock.5 Thus neonatal-specific clinical investigations, particularly in very preterm infants, are required to improve both survival and long-term outcomes for these pop­ulations. A better understanding of the pathophysiology will uncover new opportunities for interventional studies ultimately aimed at improving outcomes. To this end, in this chapter we explore the pathophysiology of sepsis in the neonate, with special attention paid to the immunobiology of sepsis." @default.
• W2892317792 created "2018-09-27" @default.
• W2892317792 creator A5020609229 @default.
• W2892317792 creator A5035778553 @default.
• W2892317792 date "2017-01-01" @default.
• W2892317792 modified "2023-09-30" @default.
• W2892317792 title "Pathophysiology of Neonatal Sepsis" @default.
• W2892317792 cites W109457554 @default.
• W2892317792 cites W133717446 @default.
• W2892317792 cites W1486737843 @default.
• W2892317792 cites W1488716186 @default.
• W2892317792 cites W1488866398 @default.
• W2892317792 cites W1499659307 @default.
• W2892317792 cites W1508769591 @default.
• W2892317792 cites W1510752733 @default.
• W2892317792 cites W1516840903 @default.
• W2892317792 cites W1531352058 @default.
• W2892317792 cites W1549427060 @default.
• W2892317792 cites W1564705518 @default.
• W2892317792 cites W1579450354 @default.
• W2892317792 cites W1594446519 @default.
• W2892317792 cites W163419591 @default.
• W2892317792 cites W1634459475 @default.
• W2892317792 cites W1661840774 @default.
• W2892317792 cites W1670573097 @default.
• W2892317792 cites W1674812699 @default.
• W2892317792 cites W1702785304 @default.
• W2892317792 cites W1721353493 @default.
• W2892317792 cites W1766228978 @default.
• W2892317792 cites W1808348270 @default.
• W2892317792 cites W1894405407 @default.
• W2892317792 cites W189708369 @default.
• W2892317792 cites W1909994536 @default.
• W2892317792 cites W1923205031 @default.
• W2892317792 cites W1926790978 @default.
• W2892317792 cites W1963808434 @default.
• W2892317792 cites W1964039094 @default.
• W2892317792 cites W1964560377 @default.
• W2892317792 cites W1964638694 @default.
• W2892317792 cites W1964948905 @default.
• W2892317792 cites W1964986858 @default.
• W2892317792 cites W1965959820 @default.
• W2892317792 cites W1966606466 @default.
• W2892317792 cites W1966855910 @default.
• W2892317792 cites W1966858538 @default.
• W2892317792 cites W1967181484 @default.
• W2892317792 cites W1967285191 @default.
• W2892317792 cites W1967286873 @default.
• W2892317792 cites W1967840465 @default.
• W2892317792 cites W1968473815 @default.
• W2892317792 cites W1969073905 @default.
• W2892317792 cites W1970196206 @default.
• W2892317792 cites W1970328266 @default.
• W2892317792 cites W1970939904 @default.
• W2892317792 cites W1971003326 @default.
• W2892317792 cites W1971915082 @default.
• W2892317792 cites W1971992928 @default.
• W2892317792 cites W1972458687 @default.
• W2892317792 cites W1973235385 @default.
• W2892317792 cites W1973417773 @default.
• W2892317792 cites W1973500095 @default.
• W2892317792 cites W1973836654 @default.
• W2892317792 cites W1974035387 @default.
• W2892317792 cites W1974247054 @default.
• W2892317792 cites W1974704963 @default.
• W2892317792 cites W1975569298 @default.
• W2892317792 cites W1975999191 @default.
• W2892317792 cites W1977160855 @default.
• W2892317792 cites W1977905350 @default.
• W2892317792 cites W1978021450 @default.
• W2892317792 cites W1978089194 @default.
• W2892317792 cites W1978331458 @default.
• W2892317792 cites W1978370373 @default.
• W2892317792 cites W1978457678 @default.
• W2892317792 cites W1978539355 @default.
• W2892317792 cites W1979304701 @default.
• W2892317792 cites W1979413706 @default.
• W2892317792 cites W1979478011 @default.
• W2892317792 cites W1980123081 @default.
• W2892317792 cites W1981243375 @default.
• W2892317792 cites W1981428052 @default.
• W2892317792 cites W1981492553 @default.
• W2892317792 cites W1981940763 @default.
• W2892317792 cites W1982484408 @default.
• W2892317792 cites W1982588557 @default.
• W2892317792 cites W1982776305 @default.
• W2892317792 cites W1982829321 @default.
• W2892317792 cites W1983372750 @default.
• W2892317792 cites W1983373642 @default.
• W2892317792 cites W1983378417 @default.
• W2892317792 cites W1984073968 @default.
• W2892317792 cites W1984226541 @default.
• W2892317792 cites W1984973599 @default.
• W2892317792 cites W1986039058 @default.
• W2892317792 cites W1986282241 @default.
• W2892317792 cites W1986609065 @default.
• W2892317792 cites W1987095281 @default.
• W2892317792 cites W1988650634 @default.

• next