Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892319563> ?p ?o ?g. }
- W2892319563 endingPage "12483" @default.
- W2892319563 startingPage "12476" @default.
- W2892319563 abstract "What is the best spatial arrangement of a pair of reactive groups for bifunctional catalysis of a chemical transformation? The conformational versatility of proteins allows reactive group geometry to be explored and optimized via evolutionary selection, but it has been difficult for chemists to identify synthetic scaffolds that allow broad comparative evaluation among alternative reactive group geometries. Here we show that a family of helices, adopted predictably by oligomers composed partially or exclusively of β-amino acid residues, enables us to explore a range of orientations for a pair of pyrrolidine units that must work in tandem to catalyze a crossed aldol reaction. Thus, the crossed aldol reaction serves as an assay of reactive diad efficacy. We have chosen a test reaction free of stereochemical complexity in order to streamline our study of reactivity. The best geometry enhances the initial rate of product formation by two orders of magnitude. Our findings raise the possibility that rudimentary catalysts involving an isolated secondary structure might have facilitated the development of prebiotic reaction networks." @default.
- W2892319563 created "2018-09-27" @default.
- W2892319563 creator A5023192029 @default.
- W2892319563 creator A5057889948 @default.
- W2892319563 date "2018-09-18" @default.
- W2892319563 modified "2023-09-25" @default.
- W2892319563 title "Exploration of Diverse Reactive Diad Geometries for Bifunctional Catalysis via Foldamer Backbone Variation" @default.
- W2892319563 cites W119240342 @default.
- W2892319563 cites W1963588863 @default.
- W2892319563 cites W1965449936 @default.
- W2892319563 cites W1990047089 @default.
- W2892319563 cites W2000050283 @default.
- W2892319563 cites W2004151060 @default.
- W2892319563 cites W2007892340 @default.
- W2892319563 cites W2011880152 @default.
- W2892319563 cites W2018371153 @default.
- W2892319563 cites W2021198082 @default.
- W2892319563 cites W2024830337 @default.
- W2892319563 cites W2032891742 @default.
- W2892319563 cites W2035299018 @default.
- W2892319563 cites W2037780945 @default.
- W2892319563 cites W2042584758 @default.
- W2892319563 cites W2052051920 @default.
- W2892319563 cites W2053463812 @default.
- W2892319563 cites W2060304557 @default.
- W2892319563 cites W2066357909 @default.
- W2892319563 cites W2071569025 @default.
- W2892319563 cites W2077196596 @default.
- W2892319563 cites W2082260955 @default.
- W2892319563 cites W2089078899 @default.
- W2892319563 cites W2096649736 @default.
- W2892319563 cites W2107025108 @default.
- W2892319563 cites W2128312954 @default.
- W2892319563 cites W2145966973 @default.
- W2892319563 cites W2167262379 @default.
- W2892319563 cites W2192797704 @default.
- W2892319563 cites W2328109222 @default.
- W2892319563 cites W2460132271 @default.
- W2892319563 cites W2520358933 @default.
- W2892319563 cites W2554179643 @default.
- W2892319563 cites W2562417815 @default.
- W2892319563 cites W2574366794 @default.
- W2892319563 cites W2594711614 @default.
- W2892319563 cites W2608862652 @default.
- W2892319563 cites W2744813064 @default.
- W2892319563 cites W2752693451 @default.
- W2892319563 cites W2762650476 @default.
- W2892319563 cites W2766627981 @default.
- W2892319563 cites W2949461420 @default.
- W2892319563 cites W4234803768 @default.
- W2892319563 cites W4236747768 @default.
- W2892319563 cites W4376453684 @default.
- W2892319563 doi "https://doi.org/10.1021/jacs.8b05869" @default.
- W2892319563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30226762" @default.
- W2892319563 hasPublicationYear "2018" @default.
- W2892319563 type Work @default.
- W2892319563 sameAs 2892319563 @default.
- W2892319563 citedByCount "27" @default.
- W2892319563 countsByYear W28923195632019 @default.
- W2892319563 countsByYear W28923195632020 @default.
- W2892319563 countsByYear W28923195632021 @default.
- W2892319563 countsByYear W28923195632022 @default.
- W2892319563 countsByYear W28923195632023 @default.
- W2892319563 crossrefType "journal-article" @default.
- W2892319563 hasAuthorship W2892319563A5023192029 @default.
- W2892319563 hasAuthorship W2892319563A5057889948 @default.
- W2892319563 hasConcept C142724271 @default.
- W2892319563 hasConcept C147597530 @default.
- W2892319563 hasConcept C15920480 @default.
- W2892319563 hasConcept C161790260 @default.
- W2892319563 hasConcept C178790620 @default.
- W2892319563 hasConcept C185592680 @default.
- W2892319563 hasConcept C204787440 @default.
- W2892319563 hasConcept C21951064 @default.
- W2892319563 hasConcept C2776910235 @default.
- W2892319563 hasConcept C2778512808 @default.
- W2892319563 hasConcept C2780443040 @default.
- W2892319563 hasConcept C35753019 @default.
- W2892319563 hasConcept C42437451 @default.
- W2892319563 hasConcept C46530973 @default.
- W2892319563 hasConcept C521977710 @default.
- W2892319563 hasConcept C61156836 @default.
- W2892319563 hasConcept C71240020 @default.
- W2892319563 hasConcept C71924100 @default.
- W2892319563 hasConceptScore W2892319563C142724271 @default.
- W2892319563 hasConceptScore W2892319563C147597530 @default.
- W2892319563 hasConceptScore W2892319563C15920480 @default.
- W2892319563 hasConceptScore W2892319563C161790260 @default.
- W2892319563 hasConceptScore W2892319563C178790620 @default.
- W2892319563 hasConceptScore W2892319563C185592680 @default.
- W2892319563 hasConceptScore W2892319563C204787440 @default.
- W2892319563 hasConceptScore W2892319563C21951064 @default.
- W2892319563 hasConceptScore W2892319563C2776910235 @default.
- W2892319563 hasConceptScore W2892319563C2778512808 @default.
- W2892319563 hasConceptScore W2892319563C2780443040 @default.
- W2892319563 hasConceptScore W2892319563C35753019 @default.
- W2892319563 hasConceptScore W2892319563C42437451 @default.
- W2892319563 hasConceptScore W2892319563C46530973 @default.