Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892319564> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2892319564 endingPage "126" @default.
- W2892319564 startingPage "126" @default.
- W2892319564 abstract "Objectives: Developing countries like India suffers mostly from cardiovascular problems and kidney failure. An antihypertensive drug is mainly used to avoid the cardiovascular problems and kidney failure. Nitrendipine is a calcium antagonist widely used in the treatment of hypertension. The bioavailability of drug, when administered orally, is low. Sustained drug delivery systems are using microspheres emerging as an effective method to increase the bioavailability of the drug. The current work involves the encapsulation of nitrendipine - acrylamide grafted chitosan which helps to overcome poor solubility and hydrophobic nature of the nitrendipine. This will enhance the drug dissolution and reduce the side effects of the antihypertensive drug.Methods: By emulsion cross-linking method, grafted copolymers were prepared. The physicochemical interactions between the drug and grafted copolymer were analyzed by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC).Results: Encapsulated drug and grafted copolymer were characterized by FTIR to understand the chemical interactions and to identify the functional groups present. Morphology and particle size of the grafted copolymer with drug and without drug were assessed by SEM. DSC was used to identify the melting endotherms of a drug, copolymer cross-linked microspheres, and drug encapsulated microspheres.Conclusion: Thus, the drug encapsulated grafted copolymer increases the hydrophilic character and thereby making the polymers feasible for functioning as drug carriers for sustained drug delivery system." @default.
- W2892319564 created "2018-09-27" @default.
- W2892319564 creator A5011128484 @default.
- W2892319564 creator A5012027847 @default.
- W2892319564 creator A5022042403 @default.
- W2892319564 creator A5081467128 @default.
- W2892319564 date "2018-09-07" @default.
- W2892319564 modified "2023-09-27" @default.
- W2892319564 title "PREPARATION AND CHARACTERIZATION OF NITRENDIPINE LOADED GRAFTED COPOLYMER MICROSPHERES: A PRELIMINARY STUDY" @default.
- W2892319564 doi "https://doi.org/10.22159/ajpcr.2018.v11i9.23733" @default.
- W2892319564 hasPublicationYear "2018" @default.
- W2892319564 type Work @default.
- W2892319564 sameAs 2892319564 @default.
- W2892319564 citedByCount "3" @default.
- W2892319564 countsByYear W28923195642020 @default.
- W2892319564 countsByYear W28923195642022 @default.
- W2892319564 crossrefType "journal-article" @default.
- W2892319564 hasAuthorship W2892319564A5011128484 @default.
- W2892319564 hasAuthorship W2892319564A5012027847 @default.
- W2892319564 hasAuthorship W2892319564A5022042403 @default.
- W2892319564 hasAuthorship W2892319564A5081467128 @default.
- W2892319564 hasBestOaLocation W28923195641 @default.
- W2892319564 hasConcept C121332964 @default.
- W2892319564 hasConcept C127413603 @default.
- W2892319564 hasConcept C15920480 @default.
- W2892319564 hasConcept C160892712 @default.
- W2892319564 hasConcept C171250308 @default.
- W2892319564 hasConcept C178790620 @default.
- W2892319564 hasConcept C181389837 @default.
- W2892319564 hasConcept C185592680 @default.
- W2892319564 hasConcept C192562407 @default.
- W2892319564 hasConcept C2779732960 @default.
- W2892319564 hasConcept C2779820397 @default.
- W2892319564 hasConcept C2780035454 @default.
- W2892319564 hasConcept C2780548744 @default.
- W2892319564 hasConcept C39519442 @default.
- W2892319564 hasConcept C42360764 @default.
- W2892319564 hasConcept C519063684 @default.
- W2892319564 hasConcept C521977710 @default.
- W2892319564 hasConcept C71924100 @default.
- W2892319564 hasConcept C97355855 @default.
- W2892319564 hasConcept C98274493 @default.
- W2892319564 hasConceptScore W2892319564C121332964 @default.
- W2892319564 hasConceptScore W2892319564C127413603 @default.
- W2892319564 hasConceptScore W2892319564C15920480 @default.
- W2892319564 hasConceptScore W2892319564C160892712 @default.
- W2892319564 hasConceptScore W2892319564C171250308 @default.
- W2892319564 hasConceptScore W2892319564C178790620 @default.
- W2892319564 hasConceptScore W2892319564C181389837 @default.
- W2892319564 hasConceptScore W2892319564C185592680 @default.
- W2892319564 hasConceptScore W2892319564C192562407 @default.
- W2892319564 hasConceptScore W2892319564C2779732960 @default.
- W2892319564 hasConceptScore W2892319564C2779820397 @default.
- W2892319564 hasConceptScore W2892319564C2780035454 @default.
- W2892319564 hasConceptScore W2892319564C2780548744 @default.
- W2892319564 hasConceptScore W2892319564C39519442 @default.
- W2892319564 hasConceptScore W2892319564C42360764 @default.
- W2892319564 hasConceptScore W2892319564C519063684 @default.
- W2892319564 hasConceptScore W2892319564C521977710 @default.
- W2892319564 hasConceptScore W2892319564C71924100 @default.
- W2892319564 hasConceptScore W2892319564C97355855 @default.
- W2892319564 hasConceptScore W2892319564C98274493 @default.
- W2892319564 hasIssue "9" @default.
- W2892319564 hasLocation W28923195641 @default.
- W2892319564 hasOpenAccess W2892319564 @default.
- W2892319564 hasPrimaryLocation W28923195641 @default.
- W2892319564 hasRelatedWork W1997550680 @default.
- W2892319564 hasRelatedWork W2051817579 @default.
- W2892319564 hasRelatedWork W2164414913 @default.
- W2892319564 hasRelatedWork W2186930905 @default.
- W2892319564 hasRelatedWork W2599027312 @default.
- W2892319564 hasRelatedWork W3091612383 @default.
- W2892319564 hasRelatedWork W3208197891 @default.
- W2892319564 hasRelatedWork W4306398900 @default.
- W2892319564 hasRelatedWork W4309352464 @default.
- W2892319564 hasRelatedWork W586787166 @default.
- W2892319564 hasVolume "11" @default.
- W2892319564 isParatext "false" @default.
- W2892319564 isRetracted "false" @default.
- W2892319564 magId "2892319564" @default.
- W2892319564 workType "article" @default.