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- W2892320798 abstract "Introduction: ODYSSEY OLE (NCT01954394) is an open-label extension (OLE) study of four Phase 3 clinical trials (FH I, FH II, LONG TERM [LTS] and HIGH FH) evaluating long-term efficacy and safety of alirocumab (ALI) in patients with heterozygous familial hypercholesterolemia (HeFH) over up to 3.5 years of treatment. Objective: ALI can be administered as 75 or 150 mg Q2W, but how this dosing strategy is applied in daily practice is largely unknown. We assessed dosing strategies used during OLE. Methods: Patients were on maximally tolerated statin +/- other lipid-lowering therapy. Patients started on ALI 75 mg Q2W (patients enrolled from HIGH FH started OLE with 150 mg Q2W and were not analyzed here). Physicians could adjust the ALI dose based on clinical judgment and LDL-C level; if further LDL-C reduction was required the ALI dose could be increased to 150 mg Q2W. Results: 909 patients (mean age 54.6 years, 56.1% male) with HeFH were analyzed. At OLE entry, HeFH patients from LTS (n=318) had a higher mean ..." @default.
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- W2892320798 date "2016-11-11" @default.
- W2892320798 modified "2023-09-27" @default.
- W2892320798 title "Abstract 16849: Alirocumab Dosing in a Real World Setting: Data From an Open-label Treatment Extension to the ODYSSEY Program for Patients With Heterozygous Familial Hypercholesterolemia" @default.
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