Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892326161> ?p ?o ?g. }
- W2892326161 abstract "The removal of afferent input to the olfactory bulb by both cautery and chemical olfactory organ ablation in adult zebrafish results in a significant decrease in volume of the ipsilateral olfactory bulb. To examine the effects of deafferentation at a cellular level, primary output neurons of the olfactory bulb, the mitral cells, were investigated using retrograde tract tracing with fluorescent dextran using ex vivo brain cultures. Morphological characteristics including the number of major dendritic branches, total length of dendritic branches, area of the dendritic arbor, overall dendritic complexity, and optical density of the arbor were used to determine the effects of deafferentation on mitral cell dendrites. Following 8 weeks of permanent deafferentation there were significant reductions in the total length of dendritic branches, the area of the dendritic arbor, and the density of fine processes in the dendritic tuft. With 8 weeks of chronic, partial deafferentation there were significant reductions in all parameters examined, including a modified Sholl analysis that showed significant decreases in overall dendritic complexity. These results show the plasticity of mitral cell dendritic structures in the adult brain and provide information about the response of these output neurons following the loss of sensory input in this key model system." @default.
- W2892326161 created "2018-09-27" @default.
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- W2892326161 date "2018-09-13" @default.
- W2892326161 modified "2023-10-08" @default.
- W2892326161 title "Deafferentation-induced alterations in mitral cell dendritic morphology in the adult zebrafish olfactory bulb" @default.
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- W2892326161 doi "https://doi.org/10.1007/s10863-018-9772-x" @default.
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