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- W2892326718 abstract "Abstract To investigate the mechanisms underlying the maintenance of neural stem cells, we performed two-dimensional fluorescence-difference gel electrophoresis (2D-DIGE) targeting the nuclear phosphorylated proteins. Nuclear phosphorylated protein Matrin-3 was identified in neural stem cells (NSCs) after stimulation using fibroblast growth factor 2 (FGF2). Matrin-3 was expressed in the mouse embryonic subventricular and ventricular zones. Small interfering RNA (siRNA)-mediated knockdown of Matrin-3 caused neuronal differentiation of NSCs in vitro , and altered the cerebral layer structure of foetal brain in vivo . Transfection of Matrin-3 plasmids in which the serine 208 residue was point-mutated to alanine (Ser208Ala mutant Matrin3) and inhibition of Ataxia telangiectasia mutated kinase (ATM kinase), which phosphorylates Matrin-3 Ser208 residue, caused neuronal differentiation and decreased the proliferation of neurosphere-forming stem cells. Thus, our proteomic approach revealed that Matrin-3 phosphorylation was essential for FGF2-dependent maintenance of NSCs in vitro and in vivo ." @default.
- W2892326718 created "2018-09-27" @default.
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- W2892326718 date "2018-09-07" @default.
- W2892326718 modified "2023-10-12" @default.
- W2892326718 title "Matrin-3 is essential for fibroblast growth factor 2-dependent maintenance of neural stem cells" @default.
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- W2892326718 doi "https://doi.org/10.1038/s41598-018-31597-x" @default.
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