FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892327612> ?p ?o ?g. }

• W2892327612 endingPage "73" @default.
• W2892327612 startingPage "57" @default.
• W2892327612 abstract "Amyloid-β oligomers (AβO) have been proposed as neurotoxins in the synaptic dysfunction that precedes Alzheimer's disease symptoms. Human and animal model studies report that senile plaques contain a halo of AβO molecules surrounding these plaques. A far smaller number of oligomers are distributed widely in plaque-free regions. It has been suggested that oligomers migrate from halos to nearby synapses and are incorporated into both pre- and postsynaptic terminals. These two types of oligomers have two different toxicities when extracted and injected in animal models. This paper proposes a shear-energy based explanation for the data in these studies. Shear hypotheses in the preceding three papers in this series are applied to suggest how the hydrodynamics and resulting shear patterns explain the spatial distribution of both AβO types, the apparent synapse loss in the vicinity of plaque particles, and possible reasons for the differing toxicities. A shear-based mechanism is proposed for the preferential migration of locally shear-excited Aβ molecules into the synaptic cleft. It is proposed that high energy laminar shear generated by the forced diversion of interstitial fluid around the flow-impeding plaque particle is responsible for the formation of AβOs around the plaque. It is suggested that in plaque-free regions, a different type of AβO with different toxicity is generated by lower energy shear flow around synapses, depositing AβO within the synapse from either the neuron membrane surface or by prion-like seeding within the synaptic cleft by locally-sheared Aβ molecules near the synapse entry." @default.
• W2892327612 created "2018-09-27" @default.
• W2892327612 creator A5018376257 @default.
• W2892327612 date "2018-10-16" @default.
• W2892327612 modified "2023-09-26" @default.
• W2892327612 title "Shear-Induced Amyloid Formation in the Brain: IV. Effects on Synapses Surrounding Senile Plaque and in Plaque-Free Regions" @default.
• W2892327612 cites W1090090111 @default.
• W2892327612 cites W1597149208 @default.
• W2892327612 cites W1767010801 @default.
• W2892327612 cites W2015640782 @default.
• W2892327612 cites W2017025451 @default.
• W2892327612 cites W2024015768 @default.
• W2892327612 cites W2027058864 @default.
• W2892327612 cites W2028623620 @default.
• W2892327612 cites W2030325989 @default.
• W2892327612 cites W2040880670 @default.
• W2892327612 cites W2042683896 @default.
• W2892327612 cites W2043191927 @default.
• W2892327612 cites W2051218719 @default.
• W2892327612 cites W2051268743 @default.
• W2892327612 cites W2062200995 @default.
• W2892327612 cites W2064751532 @default.
• W2892327612 cites W2064958479 @default.
• W2892327612 cites W2069680348 @default.
• W2892327612 cites W2072244190 @default.
• W2892327612 cites W2073656988 @default.
• W2892327612 cites W2094618353 @default.
• W2892327612 cites W2096525076 @default.
• W2892327612 cites W2101027386 @default.
• W2892327612 cites W2103440561 @default.
• W2892327612 cites W2132154794 @default.
• W2892327612 cites W2157256907 @default.
• W2892327612 cites W2164667485 @default.
• W2892327612 cites W2169135478 @default.
• W2892327612 cites W2265799967 @default.
• W2892327612 cites W2411782816 @default.
• W2892327612 cites W2511700614 @default.
• W2892327612 cites W2560790409 @default.
• W2892327612 cites W2587415506 @default.
• W2892327612 cites W2602650043 @default.
• W2892327612 cites W2724994680 @default.
• W2892327612 cites W2750355784 @default.
• W2892327612 cites W2809078375 @default.
• W2892327612 cites W2884070160 @default.
• W2892327612 doi "https://doi.org/10.3233/jad-171080" @default.
• W2892327612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6294594" @default.
• W2892327612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30223395" @default.
• W2892327612 hasPublicationYear "2018" @default.
• W2892327612 type Work @default.
• W2892327612 sameAs 2892327612 @default.
• W2892327612 citedByCount "4" @default.
• W2892327612 countsByYear W28923276122019 @default.
• W2892327612 countsByYear W28923276122021 @default.
• W2892327612 countsByYear W28923276122022 @default.
• W2892327612 crossrefType "journal-article" @default.
• W2892327612 hasAuthorship W2892327612A5018376257 @default.
• W2892327612 hasBestOaLocation W28923276121 @default.
• W2892327612 hasConcept C12554922 @default.
• W2892327612 hasConcept C127445978 @default.
• W2892327612 hasConcept C142724271 @default.
• W2892327612 hasConcept C159985019 @default.
• W2892327612 hasConcept C169760540 @default.
• W2892327612 hasConcept C170493617 @default.
• W2892327612 hasConcept C185592680 @default.
• W2892327612 hasConcept C192562407 @default.
• W2892327612 hasConcept C197341189 @default.
• W2892327612 hasConcept C200170125 @default.
• W2892327612 hasConcept C2779134260 @default.
• W2892327612 hasConcept C2993285035 @default.
• W2892327612 hasConcept C502032728 @default.
• W2892327612 hasConcept C55493867 @default.
• W2892327612 hasConcept C68026918 @default.
• W2892327612 hasConcept C71924100 @default.
• W2892327612 hasConcept C86803240 @default.
• W2892327612 hasConcept C96035792 @default.
• W2892327612 hasConceptScore W2892327612C12554922 @default.
• W2892327612 hasConceptScore W2892327612C127445978 @default.
• W2892327612 hasConceptScore W2892327612C142724271 @default.
• W2892327612 hasConceptScore W2892327612C159985019 @default.
• W2892327612 hasConceptScore W2892327612C169760540 @default.
• W2892327612 hasConceptScore W2892327612C170493617 @default.
• W2892327612 hasConceptScore W2892327612C185592680 @default.
• W2892327612 hasConceptScore W2892327612C192562407 @default.
• W2892327612 hasConceptScore W2892327612C197341189 @default.
• W2892327612 hasConceptScore W2892327612C200170125 @default.
• W2892327612 hasConceptScore W2892327612C2779134260 @default.
• W2892327612 hasConceptScore W2892327612C2993285035 @default.
• W2892327612 hasConceptScore W2892327612C502032728 @default.
• W2892327612 hasConceptScore W2892327612C55493867 @default.
• W2892327612 hasConceptScore W2892327612C68026918 @default.
• W2892327612 hasConceptScore W2892327612C71924100 @default.
• W2892327612 hasConceptScore W2892327612C86803240 @default.
• W2892327612 hasConceptScore W2892327612C96035792 @default.
• W2892327612 hasIssue "1" @default.
• W2892327612 hasLocation W28923276121 @default.
• W2892327612 hasLocation W28923276122 @default.
• W2892327612 hasLocation W28923276123 @default.
• W2892327612 hasLocation W28923276124 @default.

• next