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• W2892327944 abstract "Toxoplasma gondii is a common perorally transmitted parasite; however, its immunopathogenesis in gut-associated tissues remains unclear. Here, we compared disease manifestation in C57BL/6 immunocompetent wild type (WT) mice and immunocompromised interferon (IFN)-γ-deficient (GKO) mice after peroral infection (PI) with T. gondii cysts (Fukaya strain). Strong PI-induced Th1 cytokine expression was detected in WT mice. Moreover, bradyzoite-specific T.g.HSP30/bag1 mRNA was detected in the ileum parenchyma and Peyer's patches (PP), but not in the mesenteric lymph nodes, at 7 days post-infection in WT mice, and was significantly higher than that in GKO mice. Nested PCR showed that parasites existed in ileum parenchyma at days 1 and 1.5 post-PI in GKO and WT mice, respectively. In addition, quantitative competitive-PCR indicated that T. gondii first colonized the PP (day 3 post-PI), followed by the ileum parenchyma and mesenteric lymph nodes, spleen, and portal and aortic blood (day 7 post-PI). Although parasites were consistently more abundant in GKO mice, similar invasion and dissemination patterns were observed in the two hosts. Collectively, these data suggest that some zoites differentiate from tachyzoites to bradyzoites in the ileum and that T. gondii initially invades the ileum parenchyma, and then accumulates and proliferates in the PP before disseminating through the lymphatic systems of both GKO and WT hosts." @default.
• W2892327944 created "2018-09-27" @default.
• W2892327944 creator A5014765233 @default.
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• W2892327944 date "2019-02-01" @default.
• W2892327944 modified "2023-09-26" @default.
• W2892327944 title "Infection dynamics of Toxoplasma gondii in gut-associated tissues after oral infection: The role of Peyer's patches" @default.
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• W2892327944 doi "https://doi.org/10.1016/j.parint.2018.08.010" @default.
• W2892327944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30189256" @default.
• W2892327944 hasPublicationYear "2019" @default.
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