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- W2892331902 endingPage "174" @default.
- W2892331902 startingPage "174" @default.
- W2892331902 abstract "In this review we explore the importance of epigenetics as a contributing factor for aging adult stem cells. We summarize the latest findings of epigenetic factors deregulated as adult stem cells age and the consequence on stem cell self-renewal and differentiation, with a focus on adult stem cells in the bone marrow. With the latest whole genome bisulphite sequencing and chromatin immunoprecipitations we are able to decipher an emerging pattern common for adult stem cells in the bone marrow niche and how this might correlate to epigenetic enzymes deregulated during aging. We begin by briefly discussing the initial observations in yeast, drosophila and Caenorhabditis elegans (C. elegans) that led to the breakthrough research that identified the role of epigenetic changes associated with lifespan and aging. We then focus on adult stem cells, specifically in the bone marrow, which lends strong support for the deregulation of DNA methyltransferases, histone deacetylases, acetylates, methyltransferases and demethylases in aging stem cells, and how their corresponding epigenetic modifications influence gene expression and the aging phenotype. Given the reversible nature of epigenetic modifications we envisage epi targeted therapy as a means to reprogram aged stem cells into their younger counterparts." @default.
- W2892331902 created "2018-09-27" @default.
- W2892331902 creator A5066512567 @default.
- W2892331902 creator A5073460357 @default.
- W2892331902 date "2019-01-01" @default.
- W2892331902 modified "2023-10-08" @default.
- W2892331902 title "Epigenetic Regulation of Bone Marrow Stem Cell Aging: Revealing Epigenetic Signatures associated with Hematopoietic and Mesenchymal Stem Cell Aging" @default.
- W2892331902 cites W1481473039 @default.
- W2892331902 cites W1508556872 @default.
- W2892331902 cites W1536059425 @default.
- W2892331902 cites W1548244064 @default.
- W2892331902 cites W1548494467 @default.
- W2892331902 cites W1586705837 @default.
- W2892331902 cites W1882777418 @default.
- W2892331902 cites W1968374164 @default.
- W2892331902 cites W1968442155 @default.
- W2892331902 cites W1969288350 @default.
- W2892331902 cites W1974387660 @default.
- W2892331902 cites W1974604287 @default.
- W2892331902 cites W1974890383 @default.
- W2892331902 cites W1975420435 @default.
- W2892331902 cites W1976573435 @default.
- W2892331902 cites W1981543052 @default.
- W2892331902 cites W1984850507 @default.
- W2892331902 cites W1985308585 @default.
- W2892331902 cites W1985522353 @default.
- W2892331902 cites W1986224715 @default.
- W2892331902 cites W1987516656 @default.
- W2892331902 cites W1990646351 @default.
- W2892331902 cites W1990955843 @default.
- W2892331902 cites W1990958459 @default.
- W2892331902 cites W1991397664 @default.
- W2892331902 cites W1991962444 @default.
- W2892331902 cites W1992826811 @default.
- W2892331902 cites W1997145913 @default.
- W2892331902 cites W1997773274 @default.
- W2892331902 cites W1997998180 @default.
- W2892331902 cites W1998461585 @default.
- W2892331902 cites W1999940145 @default.
- W2892331902 cites W1999967032 @default.
- W2892331902 cites W2004247546 @default.
- W2892331902 cites W2006532804 @default.
- W2892331902 cites W2006618903 @default.
- W2892331902 cites W2007003360 @default.
- W2892331902 cites W2007188652 @default.
- W2892331902 cites W2009449023 @default.
- W2892331902 cites W2010292457 @default.
- W2892331902 cites W2011234475 @default.
- W2892331902 cites W2012860082 @default.
- W2892331902 cites W2015604890 @default.
- W2892331902 cites W2017117976 @default.
- W2892331902 cites W2017199534 @default.
- W2892331902 cites W2017840637 @default.
- W2892331902 cites W2018776959 @default.
- W2892331902 cites W2021050536 @default.
- W2892331902 cites W2028418054 @default.
- W2892331902 cites W2029969982 @default.
- W2892331902 cites W2031011363 @default.
- W2892331902 cites W2032948512 @default.
- W2892331902 cites W2033514910 @default.
- W2892331902 cites W2033613284 @default.
- W2892331902 cites W2035745747 @default.
- W2892331902 cites W2036055444 @default.
- W2892331902 cites W2037723157 @default.
- W2892331902 cites W2039669402 @default.
- W2892331902 cites W2041825762 @default.
- W2892331902 cites W2042660580 @default.
- W2892331902 cites W2044578262 @default.
- W2892331902 cites W2044767452 @default.
- W2892331902 cites W2050314360 @default.
- W2892331902 cites W2052011655 @default.
- W2892331902 cites W2055521874 @default.
- W2892331902 cites W2059383180 @default.
- W2892331902 cites W2061077538 @default.
- W2892331902 cites W2062323121 @default.
- W2892331902 cites W2063142325 @default.
- W2892331902 cites W2063544405 @default.
- W2892331902 cites W2066186764 @default.
- W2892331902 cites W2066899457 @default.
- W2892331902 cites W2071536607 @default.
- W2892331902 cites W2074746593 @default.
- W2892331902 cites W2076031927 @default.
- W2892331902 cites W207735856 @default.
- W2892331902 cites W2077498681 @default.
- W2892331902 cites W2078003979 @default.
- W2892331902 cites W2078281194 @default.
- W2892331902 cites W2078291208 @default.
- W2892331902 cites W2078489918 @default.
- W2892331902 cites W2079983476 @default.
- W2892331902 cites W2083176422 @default.
- W2892331902 cites W2083536957 @default.
- W2892331902 cites W2086875512 @default.
- W2892331902 cites W2089411743 @default.
- W2892331902 cites W2089878334 @default.
- W2892331902 cites W2090054406 @default.
- W2892331902 cites W2090529218 @default.
- W2892331902 cites W2090970088 @default.
- W2892331902 cites W2091884937 @default.