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• W2892340461 abstract "Environmental changes of biotic or abiotic nature during critical periods of early development may exert a profound influence on physiological functions later in life. This process, named developmental programming can also be driven through parental nutrition. At molecular level, epigenetic modifications are the most likely candidate for persistent modulation of genes expression in later life.In order to investigate epigenetic modifications induced by programming in rainbow trout, we focused on bnip3 and bnip3l paralogous genes known to be sensitive to environmental changes but also regulated by epigenetic modifications. Two specific stimuli were used: (i) early acute hypoxia applied at embryo stage and (ii) broodstock and fry methionine deficient diet, considering methionine as one of the main methyl-group donor needed for DNA methylation. We observed a programming effect of hypoxia with an increase of bnip3a and the four paralogs of bnip3l expression level in fry. In addition, parental methionine nutrition was correlated to bnip3a and bnip3lb1 expression showing evidence for early fry programming. We highlighted that both stimuli modified DNA methylation levels at some specific loci of bnip3a and bnip3lb1.Overall, these data demonstrate that methionine level and hypoxia stimulus can be of critical importance in metabolic programming. Both stimuli affected DNA methylation of specific loci, among them, an interesting CpG site have been identified, namely - 884 bp site of bnip3a, and may be positively related with mRNA levels." @default.
• W2892340461 created "2018-09-27" @default.
• W2892340461 creator A5005986905 @default.
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• W2892340461 date "2018-09-17" @default.
• W2892340461 modified "2023-10-09" @default.
• W2892340461 title "DNA methylation of the promoter region of bnip3 and bnip3l genes induced by metabolic programming" @default.
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• W2892340461 cites W1999732085 @default.
• W2892340461 cites W2010394923 @default.
• W2892340461 cites W2011540741 @default.
• W2892340461 cites W2011880080 @default.
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• W2892340461 cites W2032491192 @default.
• W2892340461 cites W2033531823 @default.
• W2892340461 cites W2034499270 @default.
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• W2892340461 cites W2058249219 @default.
• W2892340461 cites W2059110515 @default.
• W2892340461 cites W2060480804 @default.
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• W2892340461 cites W2082798324 @default.
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• W2892340461 cites W2148189411 @default.
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• W2892340461 doi "https://doi.org/10.1186/s12864-018-5048-4" @default.
• W2892340461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6142374" @default.
• W2892340461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30223788" @default.
• W2892340461 hasPublicationYear "2018" @default.
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