FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892342089> ?p ?o ?g. }

• W2892342089 abstract "Abstract Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets, which are source of clinical hemoderivates, such as platelet lysate (PL), routinely employed in several clinical applications as wound healing, and to preserve ex vivo the progenitor properties of the adipose stromal cells pool. So far, the presence of NPY in PL and its biological effects on the adipose stromal cell fraction (ASCs) have never been investigated. Here, we aimed to identify endogenous sources of NPY such as PL-based preparations and to investigate which biological properties PL-derived NPY is able to exert on ASCs. The results show that PL contains a high amount of NPY, which is in part also excreted by ASCs when stimulated with PL. The protein levels of the three main NPY subtype receptors (Y1, Y2, Y5) are unaltered by stimulation of ASCs with PL, but their inhibition through selective pharmacological antagonists, considerably enhances migration, and a parallel reduction of angiogenic features of ASCs including decrease in VEGF mRNA and intracellular calcium levels, both downstream targets of NPY. The expression of VEGF and NPY is enhanced within the sites of neovascularisation of difficult wounds in patients after treatment with leuco-platelet concentrates. Our data highlight the presence of NPY in PL preparations and its peripheral effects on adipose progenitors." @default.
• W2892342089 created "2018-09-27" @default.
• W2892342089 creator A5001292991 @default.
• W2892342089 creator A5011778293 @default.
• W2892342089 creator A5016221139 @default.
• W2892342089 creator A5017706465 @default.
• W2892342089 creator A5025403475 @default.
• W2892342089 creator A5051016648 @default.
• W2892342089 creator A5054249637 @default.
• W2892342089 creator A5062012442 @default.
• W2892342089 creator A5062307899 @default.
• W2892342089 creator A5065428516 @default.
• W2892342089 creator A5081957287 @default.
• W2892342089 creator A5082527578 @default.
• W2892342089 creator A5088100366 @default.
• W2892342089 creator A5088746198 @default.
• W2892342089 date "2018-09-25" @default.
• W2892342089 modified "2023-10-14" @default.
• W2892342089 title "Platelet Lysate-Derived Neuropeptide y Influences Migration and Angiogenesis of Human Adipose Tissue-Derived Stromal Cells" @default.
• W2892342089 cites W1423028119 @default.
• W2892342089 cites W1963818675 @default.
• W2892342089 cites W1966039801 @default.
• W2892342089 cites W1970653837 @default.
• W2892342089 cites W1981654602 @default.
• W2892342089 cites W1994361674 @default.
• W2892342089 cites W1996734317 @default.
• W2892342089 cites W2001786245 @default.
• W2892342089 cites W2003982930 @default.
• W2892342089 cites W2009221369 @default.
• W2892342089 cites W2012366455 @default.
• W2892342089 cites W2016176125 @default.
• W2892342089 cites W2024186814 @default.
• W2892342089 cites W2028063907 @default.
• W2892342089 cites W2037876188 @default.
• W2892342089 cites W2052052752 @default.
• W2892342089 cites W2068774971 @default.
• W2892342089 cites W2074919065 @default.
• W2892342089 cites W2080611460 @default.
• W2892342089 cites W2081758121 @default.
• W2892342089 cites W2084475906 @default.
• W2892342089 cites W2084492438 @default.
• W2892342089 cites W2085655953 @default.
• W2892342089 cites W2085792819 @default.
• W2892342089 cites W2089402670 @default.
• W2892342089 cites W2089489588 @default.
• W2892342089 cites W2090298188 @default.
• W2892342089 cites W2093598827 @default.
• W2892342089 cites W2096464209 @default.
• W2892342089 cites W2102107099 @default.
• W2892342089 cites W2106854319 @default.
• W2892342089 cites W2114382611 @default.
• W2892342089 cites W2120599904 @default.
• W2892342089 cites W2122210657 @default.
• W2892342089 cites W2123379914 @default.
• W2892342089 cites W2143303248 @default.
• W2892342089 cites W2154300848 @default.
• W2892342089 cites W2158404592 @default.
• W2892342089 cites W2165695724 @default.
• W2892342089 cites W2167213817 @default.
• W2892342089 cites W2170007502 @default.
• W2892342089 cites W2170179415 @default.
• W2892342089 cites W2256838395 @default.
• W2892342089 cites W2265084474 @default.
• W2892342089 cites W2290962415 @default.
• W2892342089 cites W2330513518 @default.
• W2892342089 cites W2399496714 @default.
• W2892342089 cites W2427132653 @default.
• W2892342089 cites W2491956847 @default.
• W2892342089 cites W2493340670 @default.
• W2892342089 cites W2497432253 @default.
• W2892342089 cites W2531945441 @default.
• W2892342089 cites W2553200079 @default.
• W2892342089 cites W2590882870 @default.
• W2892342089 cites W2594864696 @default.
• W2892342089 cites W2759017675 @default.
• W2892342089 cites W2783827486 @default.
• W2892342089 cites W2791153355 @default.
• W2892342089 cites W4565141 @default.
• W2892342089 doi "https://doi.org/10.1038/s41598-018-32623-8" @default.
• W2892342089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6156505" @default.
• W2892342089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30254326" @default.
• W2892342089 hasPublicationYear "2018" @default.
• W2892342089 type Work @default.
• W2892342089 sameAs 2892342089 @default.
• W2892342089 citedByCount "19" @default.
• W2892342089 countsByYear W28923420892019 @default.
• W2892342089 countsByYear W28923420892020 @default.
• W2892342089 countsByYear W28923420892021 @default.
• W2892342089 countsByYear W28923420892022 @default.
• W2892342089 countsByYear W28923420892023 @default.
• W2892342089 crossrefType "journal-article" @default.
• W2892342089 hasAuthorship W2892342089A5001292991 @default.
• W2892342089 hasAuthorship W2892342089A5011778293 @default.
• W2892342089 hasAuthorship W2892342089A5016221139 @default.
• W2892342089 hasAuthorship W2892342089A5017706465 @default.
• W2892342089 hasAuthorship W2892342089A5025403475 @default.
• W2892342089 hasAuthorship W2892342089A5051016648 @default.
• W2892342089 hasAuthorship W2892342089A5054249637 @default.
• W2892342089 hasAuthorship W2892342089A5062012442 @default.
• W2892342089 hasAuthorship W2892342089A5062307899 @default.

• next