Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892344763> ?p ?o ?g. }
- W2892344763 endingPage "103" @default.
- W2892344763 startingPage "92" @default.
- W2892344763 abstract "Subtle alterations in dendritic spine morphology can induce marked effects on connectivity patterns of neuronal circuits and subsequent cognitive behavior. Past studies of rodent and nonhuman primate aging revealed reductions in spine density with concomitant alterations in spine morphology among pyramidal neurons in the prefrontal cortex. In this report, we visualized and digitally reconstructed the three-dimensional morphology of dendritic spines from the dorsolateral prefrontal cortex in cognitively normal individuals aged 40-94 years. Linear models defined relationships between spines and age, Mini-Mental State Examination, apolipoprotein E (APOE) ε4 allele status, and Alzheimer's disease (AD) pathology. Similar to findings in other mammals, spine density correlated negatively with human aging. Reduced spine head diameter associated with higher Mini-Mental State Examination scores. Individuals harboring an APOE ε4 allele displayed greater numbers of dendritic filopodia and structural alterations in thin spines. The presence of AD pathology correlated with increased spine length, reduced thin spine head diameter, and increased filopodia density. Our study reveals how spine morphology in the prefrontal cortex changes in human aging and highlights key structural alterations in selective spine populations that may promote cognitively normal function despite harboring the APOE ε4 allele or AD pathology." @default.
- W2892344763 created "2018-09-27" @default.
- W2892344763 creator A5013535951 @default.
- W2892344763 creator A5054299777 @default.
- W2892344763 creator A5063529297 @default.
- W2892344763 creator A5071705223 @default.
- W2892344763 date "2019-01-01" @default.
- W2892344763 modified "2023-10-02" @default.
- W2892344763 title "Dendritic spine remodeling accompanies Alzheimer's disease pathology and genetic susceptibility in cognitively normal aging" @default.
- W2892344763 cites W1482113029 @default.
- W2892344763 cites W1577778731 @default.
- W2892344763 cites W1587505135 @default.
- W2892344763 cites W1630370318 @default.
- W2892344763 cites W1762188861 @default.
- W2892344763 cites W1775494655 @default.
- W2892344763 cites W1973311433 @default.
- W2892344763 cites W1974855479 @default.
- W2892344763 cites W1975782461 @default.
- W2892344763 cites W1978611788 @default.
- W2892344763 cites W1983509957 @default.
- W2892344763 cites W1984737558 @default.
- W2892344763 cites W1986605182 @default.
- W2892344763 cites W1989483418 @default.
- W2892344763 cites W1990752558 @default.
- W2892344763 cites W1991952617 @default.
- W2892344763 cites W1999631936 @default.
- W2892344763 cites W2001528712 @default.
- W2892344763 cites W2003569140 @default.
- W2892344763 cites W2006099191 @default.
- W2892344763 cites W2009674652 @default.
- W2892344763 cites W2011209444 @default.
- W2892344763 cites W2019249853 @default.
- W2892344763 cites W2021005581 @default.
- W2892344763 cites W2031407059 @default.
- W2892344763 cites W2033125075 @default.
- W2892344763 cites W2033833881 @default.
- W2892344763 cites W2036362108 @default.
- W2892344763 cites W2037089411 @default.
- W2892344763 cites W2042125519 @default.
- W2892344763 cites W2055875880 @default.
- W2892344763 cites W2058161128 @default.
- W2892344763 cites W2059077614 @default.
- W2892344763 cites W2063683201 @default.
- W2892344763 cites W2065400194 @default.
- W2892344763 cites W2065682784 @default.
- W2892344763 cites W2069502737 @default.
- W2892344763 cites W2070524933 @default.
- W2892344763 cites W2073101750 @default.
- W2892344763 cites W2080351494 @default.
- W2892344763 cites W2094157250 @default.
- W2892344763 cites W2099347739 @default.
- W2892344763 cites W2106267269 @default.
- W2892344763 cites W2109889898 @default.
- W2892344763 cites W2114654949 @default.
- W2892344763 cites W2117839560 @default.
- W2892344763 cites W2119060960 @default.
- W2892344763 cites W2127581769 @default.
- W2892344763 cites W2128228199 @default.
- W2892344763 cites W2129497119 @default.
- W2892344763 cites W2133470905 @default.
- W2892344763 cites W2136250824 @default.
- W2892344763 cites W2137979527 @default.
- W2892344763 cites W2139392105 @default.
- W2892344763 cites W2143175740 @default.
- W2892344763 cites W2144907160 @default.
- W2892344763 cites W2145255740 @default.
- W2892344763 cites W2146286641 @default.
- W2892344763 cites W2146729934 @default.
- W2892344763 cites W2156326104 @default.
- W2892344763 cites W2162703827 @default.
- W2892344763 cites W2165137514 @default.
- W2892344763 cites W2290598353 @default.
- W2892344763 cites W2301622264 @default.
- W2892344763 cites W2503767557 @default.
- W2892344763 cites W2755806383 @default.
- W2892344763 cites W2776516410 @default.
- W2892344763 cites W4210821588 @default.
- W2892344763 cites W4293029111 @default.
- W2892344763 doi "https://doi.org/10.1016/j.neurobiolaging.2018.09.003" @default.
- W2892344763 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6251733" @default.
- W2892344763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30339964" @default.
- W2892344763 hasPublicationYear "2019" @default.
- W2892344763 type Work @default.
- W2892344763 sameAs 2892344763 @default.
- W2892344763 citedByCount "47" @default.
- W2892344763 countsByYear W28923447632019 @default.
- W2892344763 countsByYear W28923447632020 @default.
- W2892344763 countsByYear W28923447632021 @default.
- W2892344763 countsByYear W28923447632022 @default.
- W2892344763 countsByYear W28923447632023 @default.
- W2892344763 crossrefType "journal-article" @default.
- W2892344763 hasAuthorship W2892344763A5013535951 @default.
- W2892344763 hasAuthorship W2892344763A5054299777 @default.
- W2892344763 hasAuthorship W2892344763A5063529297 @default.
- W2892344763 hasAuthorship W2892344763A5071705223 @default.
- W2892344763 hasBestOaLocation W28923447632 @default.
- W2892344763 hasConcept C105702510 @default.
- W2892344763 hasConcept C126838900 @default.