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• W2892352881 abstract "Clinical studies indicate that systemic infections accelerate cognitive decline in Alzheimer’s disease. Animal models suggest that this may be due to enhanced pro-inflammatory changes in the brain. We have performed a post-mortem human study to determine whether systemic infection modifies the neuropathology and in particular, neuroinflammation, in the late-stage of the disease. Sections of cerebral cortex and underlying white matter from controls and Alzheimer's patients who died with or without a terminal systemic infection were immunolabelled and quantified for: (i) Αβ and phosphorylated-tau; (ii) the inflammation-related proteins Iba1, CD68, HLA-DR, FcγRs (CD64, CD32a, CD32b, CD16), CHIL3L1, IL4R and CCR2; and (iii) T-cell marker CD3. In Alzheimer's disease, the synaptic proteins synaptophysin and PSD-95 were quantified by ELISA, and the inflammatory proteins and mRNAs by MesoScale Discovery Multiplex Assays and qPCR, respectively. Systemic infection in Alzheimer's disease was associated with decreased CD16 (p = 0.027, grey matter) and CD68 (p = 0.015, white matter); increased CD64 (p = 0.017, white matter) as well as increased protein expression of IL6 (p = 0.047) and decreased IL5 (p = 0.007), IL7 (p = 0.002), IL12/IL23p40 (p = 0.001), IL15 (p = 0.008), IL16 (p < 0.001) and IL17A (p < 0.001). Increased expression of anti-inflammatory genes CHI3L1 (p = 0.012) and IL4R (p = 0.004) were detected in this group. T-cell recruitment to the brain was reduced when systemic infection was present. However, exposure to systemic infection did not modify the pathology. In Alzheimer's disease, CD68 (p = 0.026), CD64 (p = 0.002), CHI3L1 (p = 0.016), IL4R (p = 0.005) and CCR2 (p = 0.010) were increased independently of systemic infection. Our findings suggest that systemic infections modify neuroinflammatory processes in Alzheimer's disease. However, rather than promoting pro-inflammatory changes, as observed in experimental models, they seem to promote an anti-inflammatory, potentially immunosuppressive, environment in the human brain." @default.
• W2892352881 created "2018-09-27" @default.
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• W2892352881 date "2018-09-07" @default.
• W2892352881 modified "2023-10-16" @default.
• W2892352881 title "Systemic infection modifies the neuroinflammatory response in late stage Alzheimer’s disease" @default.
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• W2892352881 cites W1593213689 @default.
• W2892352881 cites W1595975262 @default.
• W2892352881 cites W1667616536 @default.
• W2892352881 cites W1667783706 @default.
• W2892352881 cites W1919971299 @default.
• W2892352881 cites W1966081154 @default.
• W2892352881 cites W1966720891 @default.
• W2892352881 cites W1967399741 @default.
• W2892352881 cites W1970606114 @default.
• W2892352881 cites W1970943114 @default.
• W2892352881 cites W1971163443 @default.
• W2892352881 cites W1971695370 @default.
• W2892352881 cites W1978567629 @default.
• W2892352881 cites W1992350503 @default.
• W2892352881 cites W1993748281 @default.
• W2892352881 cites W1993929326 @default.
• W2892352881 cites W1994439483 @default.
• W2892352881 cites W2001618696 @default.
• W2892352881 cites W2004842120 @default.
• W2892352881 cites W2038604581 @default.
• W2892352881 cites W2040336122 @default.
• W2892352881 cites W2041885763 @default.
• W2892352881 cites W2041944580 @default.
• W2892352881 cites W2042580724 @default.
• W2892352881 cites W2045213688 @default.
• W2892352881 cites W2051719302 @default.
• W2892352881 cites W2054472394 @default.
• W2892352881 cites W2056912730 @default.
• W2892352881 cites W2058795549 @default.
• W2892352881 cites W2059996790 @default.
• W2892352881 cites W2064874359 @default.
• W2892352881 cites W2065210647 @default.
• W2892352881 cites W2067840722 @default.
• W2892352881 cites W2071761333 @default.
• W2892352881 cites W2073155840 @default.
• W2892352881 cites W2084670312 @default.
• W2892352881 cites W2085470664 @default.
• W2892352881 cites W2085558085 @default.
• W2892352881 cites W2087685632 @default.
• W2892352881 cites W2091975706 @default.
• W2892352881 cites W2093705034 @default.
• W2892352881 cites W2093984890 @default.
• W2892352881 cites W2094660330 @default.
• W2892352881 cites W2097867538 @default.
• W2892352881 cites W2099556150 @default.
• W2892352881 cites W2101898118 @default.
• W2892352881 cites W2107962914 @default.
• W2892352881 cites W2108435419 @default.
• W2892352881 cites W2111685488 @default.
• W2892352881 cites W2112516157 @default.
• W2892352881 cites W2122188296 @default.
• W2892352881 cites W2125380849 @default.
• W2892352881 cites W2127723018 @default.
• W2892352881 cites W2134174943 @default.
• W2892352881 cites W2134984098 @default.
• W2892352881 cites W2139406641 @default.
• W2892352881 cites W2143461767 @default.
• W2892352881 cites W2143487048 @default.
• W2892352881 cites W2144610554 @default.
• W2892352881 cites W2146729934 @default.
• W2892352881 cites W2166511841 @default.
• W2892352881 cites W2167710782 @default.
• W2892352881 cites W2205427262 @default.
• W2892352881 cites W2414662940 @default.
• W2892352881 cites W2582584573 @default.
• W2892352881 cites W2605141165 @default.
• W2892352881 cites W2615700229 @default.
• W2892352881 cites W2619332462 @default.
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• W2892352881 doi "https://doi.org/10.1186/s40478-018-0592-3" @default.
• W2892352881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6127939" @default.
• W2892352881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30193587" @default.
• W2892352881 hasPublicationYear "2018" @default.
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