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• W2892353406 endingPage "340" @default.
• W2892353406 startingPage "335" @default.
• W2892353406 abstract "RON receptor tyrosine kinase is a transmembrane protein directly involved in suppression of inflammation and its aberrant expression linked to cancers and metastasis. Efforts to block deregulated RON signaling in tumors using small molecule kinase inhibitors or antibodies have been complicated by the presence of unknown number/types of isoforms of RON, which, despite being structurally similar, localize differently and mediate varied functions. Current study was designed to identify the splice variants of RON transcripts formed by skipping of sequences between exons 9 and 14 for better understanding of isoform specific RON signaling in cancers. PCR amplification and bi-directional sequencing of a 901 bp cDNA sequence located between exons 9 to 14 of RON from lung cancer cell lines revealed the presence of two splicing variants formed by skipping of exons 11 and 11–13. Each of these transcripts was found in more than one cell line. Expressed sequence tag (EST) database search indicated that the splicing variant lacking exons 11–13 was a novel one. Here we conclude that the splice variants of RON lacking exon 11 and exons 11–13 were detected in several lung cancer cell lines. Novel variant formed by skipping exons 11–13, the sequence of which code for transmembrane region, is predicted to code for a truncated isoform that may be secreted out. Tumors may antagonize the ligand dependent anti-inflammatory function of wild-type RON by secreting out the ligand binding isoforms." @default.
• W2892353406 created "2018-09-27" @default.
• W2892353406 creator A5001780677 @default.
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• W2892353406 date "2018-12-01" @default.
• W2892353406 modified "2023-09-26" @default.
• W2892353406 title "Identification of the splice variants of Recepteur d'Origine nantais (RON) in lung cancer cell lines" @default.
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• W2892353406 doi "https://doi.org/10.1016/j.gene.2018.09.027" @default.
• W2892353406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30223007" @default.
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