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• W2892360918 startingPage "237" @default.
• W2892360918 abstract "Neurodegenerative diseases are characterized by a progressive loss of neurons that leads to a broad range of disabilities, including severe cognitive decline and motor impairment, for which there are no effective therapies. Several lines of evidence support a putative therapeutic role of nuclear receptors (NRs) in these types of disorders. NRs are ligand-activated transcription factors that regulate the expression of a wide range of genes linked to metabolism and inflammation. Although the activation of NRs in animal models of neurodegenerative disease exhibits promising results, the translation of this strategy to clinical practice has been unsuccessful. In this review we discuss the role of NRs in neurodegenerative diseases in light of preclinical and clinical studies, as well as new findings derived from the analysis of transcriptomic databases from humans and animal models. We discuss the failure in the translation of NR-based therapeutic approaches and consider alternative and novel research avenues in the development of effective therapies for neurodegenerative diseases." @default.
• W2892360918 created "2018-09-27" @default.
• W2892360918 creator A5005936452 @default.
• W2892360918 creator A5042233533 @default.
• W2892360918 creator A5054799275 @default.
• W2892360918 creator A5073496526 @default.
• W2892360918 date "2019-01-06" @default.
• W2892360918 modified "2023-09-27" @default.
• W2892360918 title "Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation" @default.
• W2892360918 cites W140465116 @default.
• W2892360918 cites W1508817480 @default.
• W2892360918 cites W1517626703 @default.
• W2892360918 cites W1523820703 @default.
• W2892360918 cites W1547774609 @default.
• W2892360918 cites W1551609960 @default.
• W2892360918 cites W1560046053 @default.
• W2892360918 cites W1579169799 @default.
• W2892360918 cites W1616122655 @default.
• W2892360918 cites W1626457406 @default.
• W2892360918 cites W1672072946 @default.
• W2892360918 cites W1685069336 @default.
• W2892360918 cites W1814421085 @default.
• W2892360918 cites W1945853828 @default.
• W2892360918 cites W1953508171 @default.
• W2892360918 cites W1968427639 @default.
• W2892360918 cites W1968448866 @default.
• W2892360918 cites W1972559333 @default.
• W2892360918 cites W1972846097 @default.
• W2892360918 cites W1973026127 @default.
• W2892360918 cites W1973756832 @default.
• W2892360918 cites W1976792807 @default.
• W2892360918 cites W1978999542 @default.
• W2892360918 cites W1979533112 @default.
• W2892360918 cites W1980020952 @default.
• W2892360918 cites W1981278455 @default.
• W2892360918 cites W1981862471 @default.
• W2892360918 cites W1991084221 @default.
• W2892360918 cites W1992456007 @default.
• W2892360918 cites W1994447059 @default.
• W2892360918 cites W1994554610 @default.
• W2892360918 cites W1997811388 @default.
• W2892360918 cites W1998314202 @default.
• W2892360918 cites W1999170657 @default.
• W2892360918 cites W2000174791 @default.
• W2892360918 cites W2000616458 @default.
• W2892360918 cites W2001269125 @default.
• W2892360918 cites W2002762124 @default.
• W2892360918 cites W2002980060 @default.
• W2892360918 cites W2003918243 @default.
• W2892360918 cites W2008582944 @default.
• W2892360918 cites W2008612961 @default.
• W2892360918 cites W2009959558 @default.
• W2892360918 cites W2010715880 @default.
• W2892360918 cites W2016787732 @default.
• W2892360918 cites W2017379833 @default.
• W2892360918 cites W2021041444 @default.
• W2892360918 cites W2023108933 @default.
• W2892360918 cites W2024037661 @default.
• W2892360918 cites W2026088200 @default.
• W2892360918 cites W2030844456 @default.
• W2892360918 cites W2033726284 @default.
• W2892360918 cites W2035515246 @default.
• W2892360918 cites W2035716975 @default.
• W2892360918 cites W2036275831 @default.
• W2892360918 cites W2037155454 @default.
• W2892360918 cites W2042449171 @default.
• W2892360918 cites W2043446856 @default.
• W2892360918 cites W2045049897 @default.
• W2892360918 cites W2047562193 @default.
• W2892360918 cites W2047673461 @default.
• W2892360918 cites W2047682339 @default.
• W2892360918 cites W2055745774 @default.
• W2892360918 cites W2059444690 @default.
• W2892360918 cites W2061151435 @default.
• W2892360918 cites W2063476471 @default.
• W2892360918 cites W2069616485 @default.
• W2892360918 cites W2070781141 @default.
• W2892360918 cites W2072822958 @default.
• W2892360918 cites W2073874214 @default.
• W2892360918 cites W2075965970 @default.
• W2892360918 cites W2080305329 @default.
• W2892360918 cites W2080995987 @default.
• W2892360918 cites W2081388499 @default.
• W2892360918 cites W2081594562 @default.
• W2892360918 cites W2082302366 @default.
• W2892360918 cites W2085284136 @default.
• W2892360918 cites W2088191717 @default.
• W2892360918 cites W2095082246 @default.
• W2892360918 cites W2095532816 @default.
• W2892360918 cites W2097178513 @default.
• W2892360918 cites W2098043716 @default.
• W2892360918 cites W2099823654 @default.
• W2892360918 cites W2105174553 @default.
• W2892360918 cites W2106489915 @default.
• W2892360918 cites W2109839766 @default.
• W2892360918 cites W2109877470 @default.
• W2892360918 cites W2114806174 @default.
• W2892360918 cites W2115389384 @default.

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