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- W2892363879 abstract "This short review aims at decrypting and analyzing the various strategies used for the synthesis of tiacumicin B. Natural products synthesis is a way for organic chemists to express inventiveness, intellectual dexterity, and elegance in strategy of synthesis. Some molecular structures are more inspiring than others; and if like tiacumicin B, the architectural challenge meets high biological and medicinal interest, the molecule can then attract the attention of many groups of synthetic chemists. 1 Introduction 2 The Strategic Challenges of this Total Synthesis 3 Construction of the C1–C5 Region 4 Construction of the C14–C19 Region 5 Construction of the C5–C12 Region 6 Construction of the C12–C15 Diene Motif 7 Macrocyclization 8 Synthesis of the Rhamnosyl Donor 9 Synthesis of the Noviosyl Donor and Glycosylation 10 The Recurrent Problems Caused by Protective Groups 11 Conclusion" @default.
- W2892363879 created "2018-09-27" @default.
- W2892363879 creator A5061599306 @default.
- W2892363879 date "2018-09-06" @default.
- W2892363879 modified "2023-10-16" @default.
- W2892363879 title "Tiacumicin B: An Antibiotic of Prime Importance and a Natural Product with an Inspiring Complex Structure" @default.
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