FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892364092> ?p ?o ?g. }

• W2892364092 endingPage "33803" @default.
• W2892364092 startingPage "33788" @default.
• W2892364092 abstract "// Sabrina Boyrie 1, 2 , Caroline Delmas 1, 2 , Anthony Lemarié 1, 3 , Vincent Lubrano 4, 5 , Perrine Dahan 1 , Laure Malric 1, 3 , José Luis 6 , Julia Gilhodes 2 , Marie Tosolini 1 , Laetitia Mouly 1, 3 , Maxime Lehmann 7 , Christine Toulas 1, 2, * , Elizabeth Cohen-Jonathan Moyal 1, 2, 3, * and Sylvie Monferran 1, 3, * 1 INSERM UMR1037, Cancer Research Center of Toulouse, Oncopole, Toulouse, France 2 Institut Claudius Regaud, IUCT-O, Toulouse, France 3 Université Toulouse III, Toulouse, France 4 INSERM UMR825, Université Toulouse III, Toulouse, France 5 Service de Neurochirurgie, Centre Hospitalier de Purpan, Université Toulouse III, Toulouse, France 6 Centre de Recherche en Oncologie biologique et Oncopharmacologie (CRO2), INSERM UMR 911, Aix-Marseille Université, Marseille, France 7 UMR 7213 CNRS, Laboratoire de Biophotonique et Pharmacologie, Tumoral Signaling and Therapeutic Targets, Université de Strasbourg, Faculté de Pharmacie, 67401 Illkirch, France * These authors contributed equally to this work Correspondence to: Sylvie Monferran, email: sylvie.monferran@inserm.fr Christine Toulas, email: toulas.christine@iuct-oncopole.fr Elizabeth Cohen-Jonathan Moyal, email: moyal.elizabeth@iuct-oncopole.fr Keywords: glioblastoma stem-like cells; periventricular zone; migration; prognostic signature; RND1 Received: February 20, 2018      Accepted: July 31, 2018      Published: September 18, 2018 ABSTRACT Despite post-operative radio-chemotherapy, glioblastoma systematically locally recurs. Tumors contacting the periventricular zone (PVZ) show earlier and more distant relapses than tumors not contacting the PVZ. Since glioblastoma stem-like cells (GSCs) have been proposed to play a major role in glioblastoma recurrence, we decided to test whether GSC migration properties could be different according to their anatomical location (PVZ+/PVZ–). For that purpose, we established paired cultures of GSCs from the cortical area (CT) and the PVZ of glioblastoma patient tumors. We demonstrated that PVZ GSCs possess higher migration and invasion capacities than CT GSCs. We highlighted specific transcriptomic profiles in PVZ versus CT populations and identified a down-regulation of the RhoGTPase, RND1 in PVZ GSCs compared to CT GSCs. Overexpression of RND1, dramatically inhibited PVZ GSC migration and conversely, downregulation of RND1 increased CT GSC migration. Additionally, transcriptomic analyses also revealed a down-regulation of RND1 in glioblastoma compared to normal brain. Using the glioblastoma TCGA database, low levels of RND1 were also shown to correlate with a decreased overall survival of patients. Finally, based on signaling pathways activated in patients with low levels of RND1 , we identified an RND1 low signature of six genes (MET, LAMC1, ITGA5, COL5A1, COL3A1, COL1A2) that is an independent prognostic factor in glioblastoma. These findings contribute to explain the shorter time to progression of patients with PVZ involvement and, point out genes that establish the RND1 low signature as key targets genes to impede tumor relapse after treatment." @default.
• W2892364092 created "2018-09-27" @default.
• W2892364092 creator A5011516812 @default.
• W2892364092 creator A5012346480 @default.
• W2892364092 creator A5017975348 @default.
• W2892364092 creator A5018948557 @default.
• W2892364092 creator A5035890801 @default.
• W2892364092 creator A5036138088 @default.
• W2892364092 creator A5039224442 @default.
• W2892364092 creator A5039389475 @default.
• W2892364092 creator A5040793238 @default.
• W2892364092 creator A5040917746 @default.
• W2892364092 creator A5041166804 @default.
• W2892364092 creator A5045626705 @default.
• W2892364092 creator A5046580775 @default.
• W2892364092 creator A5066060316 @default.
• W2892364092 date "2018-09-18" @default.
• W2892364092 modified "2023-10-18" @default.
• W2892364092 title "RND1 regulates migration of human glioblastoma stem-like cells according to their anatomical localization and defines a prognostic signature in glioblastoma" @default.
• W2892364092 cites W1072954010 @default.
• W2892364092 cites W1818313583 @default.
• W2892364092 cites W1964323367 @default.
• W2892364092 cites W1965944825 @default.
• W2892364092 cites W1972338770 @default.
• W2892364092 cites W1996118868 @default.
• W2892364092 cites W2001544973 @default.
• W2892364092 cites W2004471993 @default.
• W2892364092 cites W2009975203 @default.
• W2892364092 cites W2014342962 @default.
• W2892364092 cites W2018640258 @default.
• W2892364092 cites W2022450135 @default.
• W2892364092 cites W2024672608 @default.
• W2892364092 cites W2027098220 @default.
• W2892364092 cites W2030017878 @default.
• W2892364092 cites W2039553196 @default.
• W2892364092 cites W2040458067 @default.
• W2892364092 cites W2040607104 @default.
• W2892364092 cites W2040948261 @default.
• W2892364092 cites W2044136921 @default.
• W2892364092 cites W2051754271 @default.
• W2892364092 cites W2060551076 @default.
• W2892364092 cites W2078510083 @default.
• W2892364092 cites W2079179944 @default.
• W2892364092 cites W2087963453 @default.
• W2892364092 cites W2113942802 @default.
• W2892364092 cites W2115046420 @default.
• W2892364092 cites W2131597003 @default.
• W2892364092 cites W2134390196 @default.
• W2892364092 cites W2138198341 @default.
• W2892364092 cites W2140510391 @default.
• W2892364092 cites W2149199519 @default.
• W2892364092 cites W2150005311 @default.
• W2892364092 cites W2157183936 @default.
• W2892364092 cites W2158681922 @default.
• W2892364092 cites W2159625683 @default.
• W2892364092 cites W2161287613 @default.
• W2892364092 cites W2161289668 @default.
• W2892364092 cites W2163076992 @default.
• W2892364092 cites W2163807629 @default.
• W2892364092 cites W2165871546 @default.
• W2892364092 cites W2167414381 @default.
• W2892364092 cites W2167650288 @default.
• W2892364092 cites W2169589032 @default.
• W2892364092 cites W2258531487 @default.
• W2892364092 cites W2263206910 @default.
• W2892364092 cites W2325167642 @default.
• W2892364092 cites W2571183003 @default.
• W2892364092 cites W2606054097 @default.
• W2892364092 cites W2609595823 @default.
• W2892364092 cites W2749856153 @default.
• W2892364092 cites W2776142698 @default.
• W2892364092 cites W2951880440 @default.
• W2892364092 cites W4254029728 @default.
• W2892364092 doi "https://doi.org/10.18632/oncotarget.26082" @default.
• W2892364092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6173464" @default.
• W2892364092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30333910" @default.
• W2892364092 hasPublicationYear "2018" @default.
• W2892364092 type Work @default.
• W2892364092 sameAs 2892364092 @default.
• W2892364092 citedByCount "6" @default.
• W2892364092 countsByYear W28923640922019 @default.
• W2892364092 countsByYear W28923640922020 @default.
• W2892364092 countsByYear W28923640922022 @default.
• W2892364092 countsByYear W28923640922023 @default.
• W2892364092 crossrefType "journal-article" @default.
• W2892364092 hasAuthorship W2892364092A5011516812 @default.
• W2892364092 hasAuthorship W2892364092A5012346480 @default.
• W2892364092 hasAuthorship W2892364092A5017975348 @default.
• W2892364092 hasAuthorship W2892364092A5018948557 @default.
• W2892364092 hasAuthorship W2892364092A5035890801 @default.
• W2892364092 hasAuthorship W2892364092A5036138088 @default.
• W2892364092 hasAuthorship W2892364092A5039224442 @default.
• W2892364092 hasAuthorship W2892364092A5039389475 @default.
• W2892364092 hasAuthorship W2892364092A5040793238 @default.
• W2892364092 hasAuthorship W2892364092A5040917746 @default.
• W2892364092 hasAuthorship W2892364092A5041166804 @default.
• W2892364092 hasAuthorship W2892364092A5045626705 @default.
• W2892364092 hasAuthorship W2892364092A5046580775 @default.

• next