FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892364556> ?p ?o ?g. }

• W2892364556 abstract "Arachidonic acid (ARA, 20:4n-6) and dihomo-γ-linolenic acid (DGLA, 20:3n-6) are omega-6 long-chain polyunsaturated fatty acids (LC-PUFA), which are key precursors for lipid mediators of the immune system and inflammatory response. The microalga Lobosphaera incisa (WT) and its Δ5-desaturase mutant P127 (MUT) are unique photosynthetic sources for ARA and DGLA, respectively. This study explores the effect of dietary supplementation with L. incisa and P127 biomass on tissue fatty acid composition, immune function, and disease resistance in zebrafish (Danio rerio). The broken microalgal biomass was added to commercial fish feed at 7.5 and 15% (w/w), providing 21.8 mg/g feed ARA for the WT-supplemented group and 13.6 mg/g feed DGLA for the MUT-supplemented group at the 15% inclusion levels. An unsupplemented group was used as the control. After 1 month of feeding, fish were challenged with Streptococcus iniae. Fish were sampled before the challenge and 1 week after the challenge for various analyses. Tissue ARA and DGLA levels significantly increased in the liver, corresponding to microalgal supplementation levels. The elevated expression of specific immune-related genes was evident in the kidneys in all treatment groups after 1 month of feeding, including genes related to eicosanoid synthesis, lysozyme, and NF-κB. In the liver, microalgal supplementation led to the upregulation of genes related to immune function and antioxidant defense while the expression of examined genes involved in ARA metabolism was downregulated. Importantly, fish fed with 15% of both WT- and MUT-supplemented feed showed significantly (p < 0.05) higher survival percentages (78 and 68%, respectively, as compared to only 46% in the control group). The elevated expression of genes related to inflammatory and immune responses was evident post-challenge. Collectively, the results of the current study demonstrate the potential of microalgae-derived dietary ARA and DGLA in improving immune competence and resistance to bacterial infection in zebrafish as a model organism." @default.
• W2892364556 created "2018-09-27" @default.
• W2892364556 creator A5003670180 @default.
• W2892364556 creator A5023704773 @default.
• W2892364556 creator A5031784565 @default.
• W2892364556 creator A5080367690 @default.
• W2892364556 date "2018-09-06" @default.
• W2892364556 modified "2023-10-15" @default.
• W2892364556 title "Dietary Supplementation With ω6 LC-PUFA-Rich Algae Modulates Zebrafish Immune Function and Improves Resistance to Streptococcal Infection" @default.
• W2892364556 cites W1486027616 @default.
• W2892364556 cites W1595993343 @default.
• W2892364556 cites W1710857753 @default.
• W2892364556 cites W1907515023 @default.
• W2892364556 cites W1913572742 @default.
• W2892364556 cites W1937344726 @default.
• W2892364556 cites W1958742527 @default.
• W2892364556 cites W1965070554 @default.
• W2892364556 cites W1965188580 @default.
• W2892364556 cites W1966799784 @default.
• W2892364556 cites W1976645168 @default.
• W2892364556 cites W1986229154 @default.
• W2892364556 cites W1989696800 @default.
• W2892364556 cites W1990014836 @default.
• W2892364556 cites W1994434379 @default.
• W2892364556 cites W1997119259 @default.
• W2892364556 cites W2004782220 @default.
• W2892364556 cites W2015157276 @default.
• W2892364556 cites W2020437228 @default.
• W2892364556 cites W2022638930 @default.
• W2892364556 cites W2023083042 @default.
• W2892364556 cites W2027578097 @default.
• W2892364556 cites W2030583964 @default.
• W2892364556 cites W2033008296 @default.
• W2892364556 cites W2037174379 @default.
• W2892364556 cites W2043413905 @default.
• W2892364556 cites W2045021209 @default.
• W2892364556 cites W2049499648 @default.
• W2892364556 cites W2050214034 @default.
• W2892364556 cites W2050516487 @default.
• W2892364556 cites W2052766728 @default.
• W2892364556 cites W2059039601 @default.
• W2892364556 cites W2066505114 @default.
• W2892364556 cites W2072316970 @default.
• W2892364556 cites W2072696221 @default.
• W2892364556 cites W2073361691 @default.
• W2892364556 cites W2074989201 @default.
• W2892364556 cites W2077241366 @default.
• W2892364556 cites W2077699493 @default.
• W2892364556 cites W2083016991 @default.
• W2892364556 cites W2090880636 @default.
• W2892364556 cites W2091440910 @default.
• W2892364556 cites W2092044832 @default.
• W2892364556 cites W2097934250 @default.
• W2892364556 cites W2102858406 @default.
• W2892364556 cites W2103159301 @default.
• W2892364556 cites W2104454261 @default.
• W2892364556 cites W2107922203 @default.
• W2892364556 cites W2108962195 @default.
• W2892364556 cites W2111000934 @default.
• W2892364556 cites W2111981845 @default.
• W2892364556 cites W2120782801 @default.
• W2892364556 cites W2122534207 @default.
• W2892364556 cites W2129935236 @default.
• W2892364556 cites W2137518197 @default.
• W2892364556 cites W2138934663 @default.
• W2892364556 cites W2139213776 @default.
• W2892364556 cites W2144498097 @default.
• W2892364556 cites W2145330768 @default.
• W2892364556 cites W2145820796 @default.
• W2892364556 cites W2149026447 @default.
• W2892364556 cites W2149783560 @default.
• W2892364556 cites W2152311269 @default.
• W2892364556 cites W2154230965 @default.
• W2892364556 cites W2158743966 @default.
• W2892364556 cites W2160714033 @default.
• W2892364556 cites W2167121999 @default.
• W2892364556 cites W2170867229 @default.
• W2892364556 cites W2339778125 @default.
• W2892364556 cites W2465710624 @default.
• W2892364556 cites W2612840224 @default.
• W2892364556 cites W2733151061 @default.
• W2892364556 cites W2736714237 @default.
• W2892364556 cites W2739710852 @default.
• W2892364556 cites W2756615889 @default.
• W2892364556 cites W2791386016 @default.
• W2892364556 cites W2798244588 @default.
• W2892364556 doi "https://doi.org/10.3389/fimmu.2018.01960" @default.
• W2892364556 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6135890" @default.
• W2892364556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30237797" @default.
• W2892364556 hasPublicationYear "2018" @default.
• W2892364556 type Work @default.
• W2892364556 sameAs 2892364556 @default.
• W2892364556 citedByCount "39" @default.
• W2892364556 countsByYear W28923645562019 @default.
• W2892364556 countsByYear W28923645562020 @default.
• W2892364556 countsByYear W28923645562021 @default.
• W2892364556 countsByYear W28923645562022 @default.
• W2892364556 countsByYear W28923645562023 @default.
• W2892364556 crossrefType "journal-article" @default.
• W2892364556 hasAuthorship W2892364556A5003670180 @default.

• next