FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892367727> ?p ?o ?g. }

• W2892367727 abstract "Sulfonylureas (SUs) are widely prescribed for the treatment of type 2 diabetes (T2DM). Sulfonylurea receptors (SURs) are their main functional receptors. These receptors are also found in kidney, especially the tubular cells. However, the effects of SUs on renal proximal tubular epithelial cells (PTECs) were unclear.Three commonly used SUs were included in this study to investigate if different SUs have different effects on the apoptosis of PTECs. HK-2 cells were exposed to SUs for 24 h prior to exposure to 30 mM glucose, the apoptosis rate was evaluated by Annexin/PI flow cytometry. Bcl-2, Bax and the ratio of LC3II to LC3I were also studied by western blot in vitro. Diazoxide was used to evaluate the role of KATP channel in SUs-induced apoptosis of PTECs. A Student's t-test was used to assess significance for data within two groups.Treatment with glibenclamide aggravated the apoptosis of HK-2 cells in high-glucose, as indicated by a significant decrease in the expression of Bcl-2 and increase in Bax. Additionally, the decreased LC3II/LC3I reflects that the autophagy was inhibited by glibenclamide. Similar but less pronounced change was found in glimepiride group, however, nearly opposite effects were found in gliclazide group. Further, the effects of glibenclamide on apoptosis promotion and the decreased LC3II/LC3I were ameliorated obviously by treatment with 100uM diazoxide. The potential protection effect of gliclazide was also inhibited after opening the KATP channel.Our results suggest that, the effects of glibenclamide and glimepiride on PTECs apoptosis, especially the former, were achieved in part by closing the KATP channel. In contrast to glibenclamide and glimepiride, therapeutic concentrations of gliclazide showed an inhibitory effect on apoptosis of PTECs, which may have a benefit in the preservation of functional PTECs mass." @default.
• W2892367727 created "2018-09-27" @default.
• W2892367727 creator A5002551939 @default.
• W2892367727 creator A5009366951 @default.
• W2892367727 creator A5009464342 @default.
• W2892367727 creator A5031646804 @default.
• W2892367727 creator A5031873259 @default.
• W2892367727 creator A5050626282 @default.
• W2892367727 creator A5063583435 @default.
• W2892367727 creator A5065037360 @default.
• W2892367727 date "2018-09-04" @default.
• W2892367727 modified "2023-10-16" @default.
• W2892367727 title "Different sulfonylureas induce the apoptosis of proximal tubular epithelial cell differently via closing KATP channel" @default.
• W2892367727 cites W1555144527 @default.
• W2892367727 cites W1899289933 @default.
• W2892367727 cites W1945441090 @default.
• W2892367727 cites W1946560060 @default.
• W2892367727 cites W1965882905 @default.
• W2892367727 cites W1969616819 @default.
• W2892367727 cites W1970535109 @default.
• W2892367727 cites W1983867754 @default.
• W2892367727 cites W1986804446 @default.
• W2892367727 cites W1988838635 @default.
• W2892367727 cites W1989173323 @default.
• W2892367727 cites W1994971084 @default.
• W2892367727 cites W1997406551 @default.
• W2892367727 cites W1998401231 @default.
• W2892367727 cites W2001902542 @default.
• W2892367727 cites W2003142889 @default.
• W2892367727 cites W2003692413 @default.
• W2892367727 cites W2008677894 @default.
• W2892367727 cites W2024184215 @default.
• W2892367727 cites W2025257765 @default.
• W2892367727 cites W2026412750 @default.
• W2892367727 cites W2027808216 @default.
• W2892367727 cites W2031308048 @default.
• W2892367727 cites W2031552776 @default.
• W2892367727 cites W2034772537 @default.
• W2892367727 cites W2037266025 @default.
• W2892367727 cites W2046667492 @default.
• W2892367727 cites W2046749494 @default.
• W2892367727 cites W2052343685 @default.
• W2892367727 cites W2055189403 @default.
• W2892367727 cites W2059328843 @default.
• W2892367727 cites W2074029585 @default.
• W2892367727 cites W2079555649 @default.
• W2892367727 cites W2083584165 @default.
• W2892367727 cites W2093478842 @default.
• W2892367727 cites W2101721772 @default.
• W2892367727 cites W2106481293 @default.
• W2892367727 cites W2115386661 @default.
• W2892367727 cites W2117813164 @default.
• W2892367727 cites W2127979151 @default.
• W2892367727 cites W2154104320 @default.
• W2892367727 cites W2158446662 @default.
• W2892367727 cites W2162254199 @default.
• W2892367727 cites W2166039491 @default.
• W2892367727 cites W2167078761 @default.
• W2892367727 cites W2172211138 @default.
• W2892367727 cites W2303118595 @default.
• W2892367727 cites W2366615711 @default.
• W2892367727 cites W2415143293 @default.
• W2892367727 cites W2441313541 @default.
• W2892367727 cites W2475271811 @default.
• W2892367727 cites W2475311184 @default.
• W2892367727 cites W2591538371 @default.
• W2892367727 cites W4231136008 @default.
• W2892367727 cites W4232119336 @default.
• W2892367727 doi "https://doi.org/10.1186/s10020-018-0042-5" @default.
• W2892367727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6122448" @default.
• W2892367727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30180807" @default.
• W2892367727 hasPublicationYear "2018" @default.
• W2892367727 type Work @default.
• W2892367727 sameAs 2892367727 @default.
• W2892367727 citedByCount "6" @default.
• W2892367727 countsByYear W28923677272019 @default.
• W2892367727 countsByYear W28923677272021 @default.
• W2892367727 countsByYear W28923677272022 @default.
• W2892367727 countsByYear W28923677272023 @default.
• W2892367727 crossrefType "journal-article" @default.
• W2892367727 hasAuthorship W2892367727A5002551939 @default.
• W2892367727 hasAuthorship W2892367727A5009366951 @default.
• W2892367727 hasAuthorship W2892367727A5009464342 @default.
• W2892367727 hasAuthorship W2892367727A5031646804 @default.
• W2892367727 hasAuthorship W2892367727A5031873259 @default.
• W2892367727 hasAuthorship W2892367727A5050626282 @default.
• W2892367727 hasAuthorship W2892367727A5063583435 @default.
• W2892367727 hasAuthorship W2892367727A5065037360 @default.
• W2892367727 hasBestOaLocation W28923677271 @default.
• W2892367727 hasConcept C102942909 @default.
• W2892367727 hasConcept C126322002 @default.
• W2892367727 hasConcept C134018914 @default.
• W2892367727 hasConcept C170493617 @default.
• W2892367727 hasConcept C185592680 @default.
• W2892367727 hasConcept C190283241 @default.
• W2892367727 hasConcept C203522944 @default.
• W2892367727 hasConcept C2776307423 @default.
• W2892367727 hasConcept C2777180221 @default.
• W2892367727 hasConcept C2777448766 @default.
• W2892367727 hasConcept C2779306644 @default.

• next