Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892371760> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2892371760 endingPage "810" @default.
- W2892371760 startingPage "803" @default.
- W2892371760 abstract "Introduction: Ganaplacide (previously known as KAF156) is a novel antimalarial compound part of the imidazolopiperazine family.Areas covered: At the time of writing, a total of eight studies addressing its preclinical and clinical development have been published on this compound, which is currently in phase 2 of clinical development, alongside lumefantrine in a novel soluble formulation as combination partner. This review provides an overview and interpretation of the published pre-clinical and clinical data of this possible next-generation antimalarial drug.Expert opinion: In the search for a ‘magic bullet’ in malaria therapy and prophylaxis facilitating single encounter radical cure and prophylaxis, ganaplacide demonstrates some promising properties toward this ultimate goal. The available data suggest that ganaplacide exerts multi-stage antimalarial activity, and that its pharmacokinetic profile potentially allows for a simplified dosing regimen compared to that of existing antimalarial drug combinations. The first in-patient results demonstrate promising single-dose antimalarial activity, and no serious in-human safety and tolerability concerns have been reported to date." @default.
- W2892371760 created "2018-09-27" @default.
- W2892371760 creator A5013340768 @default.
- W2892371760 creator A5052357263 @default.
- W2892371760 creator A5087477162 @default.
- W2892371760 date "2018-09-25" @default.
- W2892371760 modified "2023-10-12" @default.
- W2892371760 title "The early preclinical and clinical development of ganaplacide (KAF156), a novel antimalarial compound" @default.
- W2892371760 cites W2038072533 @default.
- W2892371760 cites W2055394098 @default.
- W2892371760 cites W2064949809 @default.
- W2892371760 cites W2135797423 @default.
- W2892371760 cites W2324532962 @default.
- W2892371760 cites W2419603346 @default.
- W2892371760 cites W2467259677 @default.
- W2892371760 cites W2491703515 @default.
- W2892371760 cites W2522186830 @default.
- W2892371760 cites W2522966114 @default.
- W2892371760 cites W2565054976 @default.
- W2892371760 cites W2621796664 @default.
- W2892371760 cites W2641848379 @default.
- W2892371760 cites W2786619358 @default.
- W2892371760 cites W2793223380 @default.
- W2892371760 cites W2799282155 @default.
- W2892371760 cites W2886706562 @default.
- W2892371760 cites W4242588288 @default.
- W2892371760 cites W620719690 @default.
- W2892371760 doi "https://doi.org/10.1080/13543784.2018.1524871" @default.
- W2892371760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30223692" @default.
- W2892371760 hasPublicationYear "2018" @default.
- W2892371760 type Work @default.
- W2892371760 sameAs 2892371760 @default.
- W2892371760 citedByCount "13" @default.
- W2892371760 countsByYear W28923717602019 @default.
- W2892371760 countsByYear W28923717602020 @default.
- W2892371760 countsByYear W28923717602021 @default.
- W2892371760 countsByYear W28923717602022 @default.
- W2892371760 countsByYear W28923717602023 @default.
- W2892371760 crossrefType "journal-article" @default.
- W2892371760 hasAuthorship W2892371760A5013340768 @default.
- W2892371760 hasAuthorship W2892371760A5052357263 @default.
- W2892371760 hasAuthorship W2892371760A5087477162 @default.
- W2892371760 hasConcept C126322002 @default.
- W2892371760 hasConcept C141071460 @default.
- W2892371760 hasConcept C177713679 @default.
- W2892371760 hasConcept C197934379 @default.
- W2892371760 hasConcept C203014093 @default.
- W2892371760 hasConcept C2777288759 @default.
- W2892371760 hasConcept C2778048844 @default.
- W2892371760 hasConcept C2778375690 @default.
- W2892371760 hasConcept C2780035454 @default.
- W2892371760 hasConcept C2781413609 @default.
- W2892371760 hasConcept C2992152733 @default.
- W2892371760 hasConcept C3020580240 @default.
- W2892371760 hasConcept C535046627 @default.
- W2892371760 hasConcept C60644358 @default.
- W2892371760 hasConcept C64903051 @default.
- W2892371760 hasConcept C71924100 @default.
- W2892371760 hasConcept C86803240 @default.
- W2892371760 hasConcept C98274493 @default.
- W2892371760 hasConceptScore W2892371760C126322002 @default.
- W2892371760 hasConceptScore W2892371760C141071460 @default.
- W2892371760 hasConceptScore W2892371760C177713679 @default.
- W2892371760 hasConceptScore W2892371760C197934379 @default.
- W2892371760 hasConceptScore W2892371760C203014093 @default.
- W2892371760 hasConceptScore W2892371760C2777288759 @default.
- W2892371760 hasConceptScore W2892371760C2778048844 @default.
- W2892371760 hasConceptScore W2892371760C2778375690 @default.
- W2892371760 hasConceptScore W2892371760C2780035454 @default.
- W2892371760 hasConceptScore W2892371760C2781413609 @default.
- W2892371760 hasConceptScore W2892371760C2992152733 @default.
- W2892371760 hasConceptScore W2892371760C3020580240 @default.
- W2892371760 hasConceptScore W2892371760C535046627 @default.
- W2892371760 hasConceptScore W2892371760C60644358 @default.
- W2892371760 hasConceptScore W2892371760C64903051 @default.
- W2892371760 hasConceptScore W2892371760C71924100 @default.
- W2892371760 hasConceptScore W2892371760C86803240 @default.
- W2892371760 hasConceptScore W2892371760C98274493 @default.
- W2892371760 hasIssue "10" @default.
- W2892371760 hasLocation W28923717601 @default.
- W2892371760 hasLocation W28923717602 @default.
- W2892371760 hasOpenAccess W2892371760 @default.
- W2892371760 hasPrimaryLocation W28923717601 @default.
- W2892371760 hasRelatedWork W1990197915 @default.
- W2892371760 hasRelatedWork W2087016115 @default.
- W2892371760 hasRelatedWork W2305775430 @default.
- W2892371760 hasRelatedWork W2427186628 @default.
- W2892371760 hasRelatedWork W2465571689 @default.
- W2892371760 hasRelatedWork W2915644342 @default.
- W2892371760 hasRelatedWork W3166797618 @default.
- W2892371760 hasRelatedWork W3191427281 @default.
- W2892371760 hasRelatedWork W4210913627 @default.
- W2892371760 hasRelatedWork W4311628015 @default.
- W2892371760 hasVolume "27" @default.
- W2892371760 isParatext "false" @default.
- W2892371760 isRetracted "false" @default.
- W2892371760 magId "2892371760" @default.
- W2892371760 workType "article" @default.