Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892374987> ?p ?o ?g. }
- W2892374987 abstract "Early mammalian development is crucially dependent on the establishment of oxidative energy metabolism within the trophectoderm (TE) lineage. Unlike the inner cell mass, TE cells enhance ATP production via mitochondrial oxidative phosphorylation (OXPHOS) and this metabolic preference is essential for blastocyst maturation. However, molecular mechanisms that regulate establishment of oxidative energy metabolism in TE cells are incompletely understood. Here, we show that conserved transcription factor TEAD4, which is essential for pre-implantation mammalian development, regulates this process by promoting mitochondrial transcription. In developing mouse TE and TE-derived trophoblast stem cells (TSCs), TEAD4 localizes to mitochondria, binds to mitochondrial DNA (mtDNA) and facilitates its transcription by recruiting mitochondrial RNA polymerase (POLRMT). Loss of TEAD4 impairs recruitment of POLRMT, resulting in reduced expression of mtDNA-encoded electron transport chain components, thereby inhibiting oxidative energy metabolism. Our studies identify a novel TEAD4-dependent molecular mechanism that regulates energy metabolism in the TE lineage to ensure mammalian development." @default.
- W2892374987 created "2018-09-27" @default.
- W2892374987 creator A5014834868 @default.
- W2892374987 creator A5016596623 @default.
- W2892374987 creator A5030996214 @default.
- W2892374987 creator A5031124359 @default.
- W2892374987 creator A5032746085 @default.
- W2892374987 creator A5044548008 @default.
- W2892374987 creator A5050249978 @default.
- W2892374987 creator A5050470588 @default.
- W2892374987 creator A5051833773 @default.
- W2892374987 creator A5056114856 @default.
- W2892374987 creator A5065451110 @default.
- W2892374987 creator A5084676486 @default.
- W2892374987 creator A5090813047 @default.
- W2892374987 date "2018-10-01" @default.
- W2892374987 modified "2023-10-14" @default.
- W2892374987 title "Regulation of energy metabolism during early mammalian development: TEAD4 controls mitochondrial transcription." @default.
- W2892374987 cites W113327114 @default.
- W2892374987 cites W1223322285 @default.
- W2892374987 cites W1492956840 @default.
- W2892374987 cites W1514520124 @default.
- W2892374987 cites W1548912336 @default.
- W2892374987 cites W1797018503 @default.
- W2892374987 cites W1816428770 @default.
- W2892374987 cites W1856939756 @default.
- W2892374987 cites W1874303456 @default.
- W2892374987 cites W1939279832 @default.
- W2892374987 cites W1968197570 @default.
- W2892374987 cites W1971582979 @default.
- W2892374987 cites W1974386896 @default.
- W2892374987 cites W1974864674 @default.
- W2892374987 cites W1981516020 @default.
- W2892374987 cites W1982160073 @default.
- W2892374987 cites W1982749096 @default.
- W2892374987 cites W1985538633 @default.
- W2892374987 cites W1989207860 @default.
- W2892374987 cites W1995169990 @default.
- W2892374987 cites W2000860344 @default.
- W2892374987 cites W2001528107 @default.
- W2892374987 cites W2003479624 @default.
- W2892374987 cites W2004102023 @default.
- W2892374987 cites W2004878069 @default.
- W2892374987 cites W2007634751 @default.
- W2892374987 cites W2009397177 @default.
- W2892374987 cites W2012305943 @default.
- W2892374987 cites W2014042535 @default.
- W2892374987 cites W2016369333 @default.
- W2892374987 cites W2018448923 @default.
- W2892374987 cites W2020234481 @default.
- W2892374987 cites W2022664710 @default.
- W2892374987 cites W2027345455 @default.
- W2892374987 cites W2028339345 @default.
- W2892374987 cites W2028895543 @default.
- W2892374987 cites W2030456165 @default.
- W2892374987 cites W2031911979 @default.
- W2892374987 cites W2038481472 @default.
- W2892374987 cites W2040232631 @default.
- W2892374987 cites W2041255962 @default.
- W2892374987 cites W2042094767 @default.
- W2892374987 cites W2053482584 @default.
- W2892374987 cites W2054815524 @default.
- W2892374987 cites W2060553298 @default.
- W2892374987 cites W2062691001 @default.
- W2892374987 cites W2068325863 @default.
- W2892374987 cites W2068565752 @default.
- W2892374987 cites W2070392246 @default.
- W2892374987 cites W2073095545 @default.
- W2892374987 cites W2075172171 @default.
- W2892374987 cites W2079174004 @default.
- W2892374987 cites W2079892110 @default.
- W2892374987 cites W2081360068 @default.
- W2892374987 cites W2085577928 @default.
- W2892374987 cites W2092578153 @default.
- W2892374987 cites W2100848073 @default.
- W2892374987 cites W2108059964 @default.
- W2892374987 cites W2126194787 @default.
- W2892374987 cites W2128877497 @default.
- W2892374987 cites W2130273514 @default.
- W2892374987 cites W2143309533 @default.
- W2892374987 cites W2144082713 @default.
- W2892374987 cites W2146119109 @default.
- W2892374987 cites W2147145982 @default.
- W2892374987 cites W2148171335 @default.
- W2892374987 cites W2158030172 @default.
- W2892374987 cites W2162006879 @default.
- W2892374987 cites W2165960631 @default.
- W2892374987 cites W2167091449 @default.
- W2892374987 cites W2167503858 @default.
- W2892374987 cites W2170439599 @default.
- W2892374987 cites W2215582843 @default.
- W2892374987 cites W2284282032 @default.
- W2892374987 cites W2335993996 @default.
- W2892374987 cites W2419175294 @default.
- W2892374987 cites W2476107434 @default.
- W2892374987 cites W2769954814 @default.
- W2892374987 cites W565439874 @default.
- W2892374987 cites W99891715 @default.
- W2892374987 doi "https://doi.org/10.1242/dev.162644" @default.
- W2892374987 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6198476" @default.