FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892379715> ?p ?o ?g. }

• W2892379715 endingPage "11948" @default.
• W2892379715 startingPage "11941" @default.
• W2892379715 abstract "The relationship between amine submetabolome and cancer has been increasingly investigated. However, no study was performed to evaluate the current methods of amine submetabolomics comprehensively, or to use such quantification results to provide an applicable approach for cancer screening. In this study, a highly sensitive and practical workflow for quantifying amine submetabolome, which was based on 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC)-labeled-HPLC-MS/MS analysis combined with multiple statistical data processing approach, was established and optimized. Comparison and optimization of two analytical approaches, HILIC separation and precolumn derivatization, and three types of surrogate matrices of plasma were performed systematically. The detection sensitivities of AQC-labeled amines were increased by 50–1000-fold compared with the underivatization-HILIC method. Surrogate matrix was also used to verify the method after a large dilution factor was employed. In data analysis, the specific amino-index for each cancer sample was identified and validated by univariate receiver operating characteristic (ROC) curve analysis, partial least-squares discrimination analysis (PLS-DA), and multivariate ROC curve analysis. These amino indexes were innovatively quantified by multiplying the raised markers and dividing the reduced markers. As a result, the numerical intervals of amino indexes for healthy volunteers and cancer patients were provided, and their clinical value was also improved. Finally, the integrated workflow successfully differentiated the value of the amino index for plasma of lung, breast, colorectal, and gastric cancer samples from controls and among different types of cancer. Furthermore, it was also used to evaluate therapeutic effects. Taken together, the developed methodology, which was characterized by high sensitivity, high throughput, and high practicality, is suitable for amine submetabolomics in studying cancer biomarkers and could also be applied in many other clinical and epidemiological research." @default.
• W2892379715 created "2018-09-27" @default.
• W2892379715 creator A5002063716 @default.
• W2892379715 creator A5005210500 @default.
• W2892379715 creator A5006733112 @default.
• W2892379715 creator A5047138797 @default.
• W2892379715 creator A5052441498 @default.
• W2892379715 creator A5053780153 @default.
• W2892379715 creator A5059142323 @default.
• W2892379715 creator A5070245791 @default.
• W2892379715 creator A5075716358 @default.
• W2892379715 creator A5081489339 @default.
• W2892379715 date "2018-09-12" @default.
• W2892379715 modified "2023-10-12" @default.
• W2892379715 title "Highly Sensitive Quantification Method for Amine Submetabolome Based on AQC-Labeled-LC-Tandem-MS and Multiple Statistical Data Mining: A Potential Cancer Screening Approach" @default.
• W2892379715 cites W1966512413 @default.
• W2892379715 cites W1971689215 @default.
• W2892379715 cites W1974267906 @default.
• W2892379715 cites W1974856655 @default.
• W2892379715 cites W1977078171 @default.
• W2892379715 cites W1979794366 @default.
• W2892379715 cites W1986517285 @default.
• W2892379715 cites W1992654016 @default.
• W2892379715 cites W1997975781 @default.
• W2892379715 cites W2005463280 @default.
• W2892379715 cites W2020182172 @default.
• W2892379715 cites W2031212516 @default.
• W2892379715 cites W2047950884 @default.
• W2892379715 cites W2050628547 @default.
• W2892379715 cites W2058249282 @default.
• W2892379715 cites W2059383952 @default.
• W2892379715 cites W2082425281 @default.
• W2892379715 cites W2093145625 @default.
• W2892379715 cites W2108354906 @default.
• W2892379715 cites W2111076478 @default.
• W2892379715 cites W2125181296 @default.
• W2892379715 cites W2131560480 @default.
• W2892379715 cites W2135989615 @default.
• W2892379715 cites W2140695271 @default.
• W2892379715 cites W2154496747 @default.
• W2892379715 cites W2157579566 @default.
• W2892379715 cites W2167533746 @default.
• W2892379715 cites W2190934640 @default.
• W2892379715 cites W2271911760 @default.
• W2892379715 cites W2334822634 @default.
• W2892379715 cites W2335445078 @default.
• W2892379715 cites W2344053145 @default.
• W2892379715 cites W2345968351 @default.
• W2892379715 cites W2410161275 @default.
• W2892379715 cites W2529503248 @default.
• W2892379715 cites W2539494034 @default.
• W2892379715 cites W2566944468 @default.
• W2892379715 cites W2578450331 @default.
• W2892379715 cites W2614737449 @default.
• W2892379715 cites W2735370943 @default.
• W2892379715 cites W2767617925 @default.
• W2892379715 cites W2800473669 @default.
• W2892379715 cites W2884982138 @default.
• W2892379715 doi "https://doi.org/10.1021/acs.analchem.8b02372" @default.
• W2892379715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30208276" @default.
• W2892379715 hasPublicationYear "2018" @default.
• W2892379715 type Work @default.
• W2892379715 sameAs 2892379715 @default.
• W2892379715 citedByCount "16" @default.
• W2892379715 countsByYear W28923797152019 @default.
• W2892379715 countsByYear W28923797152020 @default.
• W2892379715 countsByYear W28923797152021 @default.
• W2892379715 countsByYear W28923797152022 @default.
• W2892379715 countsByYear W28923797152023 @default.
• W2892379715 crossrefType "journal-article" @default.
• W2892379715 hasAuthorship W2892379715A5002063716 @default.
• W2892379715 hasAuthorship W2892379715A5005210500 @default.
• W2892379715 hasAuthorship W2892379715A5006733112 @default.
• W2892379715 hasAuthorship W2892379715A5047138797 @default.
• W2892379715 hasAuthorship W2892379715A5052441498 @default.
• W2892379715 hasAuthorship W2892379715A5053780153 @default.
• W2892379715 hasAuthorship W2892379715A5059142323 @default.
• W2892379715 hasAuthorship W2892379715A5070245791 @default.
• W2892379715 hasAuthorship W2892379715A5075716358 @default.
• W2892379715 hasAuthorship W2892379715A5081489339 @default.
• W2892379715 hasConcept C119857082 @default.
• W2892379715 hasConcept C121608353 @default.
• W2892379715 hasConcept C126322002 @default.
• W2892379715 hasConcept C161584116 @default.
• W2892379715 hasConcept C185592680 @default.
• W2892379715 hasConcept C199163554 @default.
• W2892379715 hasConcept C22354355 @default.
• W2892379715 hasConcept C41008148 @default.
• W2892379715 hasConcept C43617362 @default.
• W2892379715 hasConcept C58471807 @default.
• W2892379715 hasConcept C71924100 @default.
• W2892379715 hasConceptScore W2892379715C119857082 @default.
• W2892379715 hasConceptScore W2892379715C121608353 @default.
• W2892379715 hasConceptScore W2892379715C126322002 @default.
• W2892379715 hasConceptScore W2892379715C161584116 @default.
• W2892379715 hasConceptScore W2892379715C185592680 @default.
• W2892379715 hasConceptScore W2892379715C199163554 @default.
• W2892379715 hasConceptScore W2892379715C22354355 @default.

• next