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- W2892381229 abstract "Unlike most other model eukaryotes, Trypanosoma brucei and its relatives have a single mitochondrion with a single-unit mitochondrial genome that is termed kinetoplast DNA (kDNA). Replication of the kDNA is coordinated with the cell cycle. During binary mitochondrial fission and prior to cytokinesis, the replicated kDNA has to be faithfully segregated to the daughter organelles. This process depends on the tripartite attachment complex (TAC) that physically links the kDNA across the two mitochondrial membranes with the basal body of the flagellum. Thus, the TAC couples segregation of the replicated kDNA with segregation of the basal bodies of the old and the new flagellum. In this Review, we provide an overview of the role of the TAC in kDNA inheritance in T. brucei We focus on recent advances regarding the molecular composition of the TAC, and discuss how the TAC is assembled and how its subunits are targeted to their respective TAC subdomains. Finally, we will contrast the segregation of the single-unit kDNA in trypanosomes to mitochondrial genome inheritance in yeast and mammals, both of which have numerous mitochondria that each contain multiple genomes." @default.
- W2892381229 created "2018-09-27" @default.
- W2892381229 creator A5007189277 @default.
- W2892381229 creator A5061301386 @default.
- W2892381229 date "2018-09-15" @default.
- W2892381229 modified "2023-10-15" @default.
- W2892381229 title "Failure is not an option – mitochondrial genome segregation in trypanosomes" @default.
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- W2892381229 doi "https://doi.org/10.1242/jcs.221820" @default.
- W2892381229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30224426" @default.
- W2892381229 hasPublicationYear "2018" @default.
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