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- W2892387910 abstract "As human co-exposure to natural toxins through food and water is inevitable, risk assessments to safeguard health are necessary. Aflatoxin B1 and fumonisin B1, frequent co-contaminants of maize and microcystin-LR, produced in freshwater by cyanobacteria are all naturally occurring potent toxins that threaten human health. Populations in the poorest regions of the world may suffer repeated simultaneous exposure to these contaminants. Using High Content Analysis, multiple cytotoxicity endpoints were measured for the individual toxins and mixtures in various cell lines. Results highlighted that significant cytotoxic effects were observed for aflatoxin B1 in all cell lines while no cytotoxic effects were observed for fumonisin B1 or microcystin-LR. Aflatoxin B1/microcystin-LR was cytotoxic in the order HepG2 > Caco-2 > MDBK. Fumonisin B1/microcystin-LR affected MDBK cells. The ternary mixture was cytotoxic to all cell lines. Most combinations were additive, however antagonism was observed for binary and ternary mixtures in HepG2 and MDBK cell lines at low and high concentrations. Synergy was observed in all cell lines, including at low concentrations. The combination of these natural toxins may pose a significant risk to populations in less developed countries. Furthermore, the study highlights the complexity around trying to regulate for human exposure to multiple contaminants." @default.
- W2892387910 created "2018-10-05" @default.
- W2892387910 creator A5015671913 @default.
- W2892387910 creator A5017963229 @default.
- W2892387910 creator A5018276777 @default.
- W2892387910 creator A5024014610 @default.
- W2892387910 date "2018-11-01" @default.
- W2892387910 modified "2023-09-27" @default.
- W2892387910 title "Assessing the combined toxicity of the natural toxins, aflatoxin B1, fumonisin B1 and microcystin-LR by high content analysis" @default.
- W2892387910 cites W1234381643 @default.
- W2892387910 cites W1519012557 @default.
- W2892387910 cites W1803067343 @default.
- W2892387910 cites W1969967479 @default.
- W2892387910 cites W1979006706 @default.
- W2892387910 cites W1979109200 @default.
- W2892387910 cites W1979378857 @default.
- W2892387910 cites W1980455299 @default.
- W2892387910 cites W1980505601 @default.
- W2892387910 cites W1985720650 @default.
- W2892387910 cites W1988228934 @default.
- W2892387910 cites W1993763703 @default.
- W2892387910 cites W1995042037 @default.
- W2892387910 cites W1995926267 @default.
- W2892387910 cites W1998899598 @default.
- W2892387910 cites W2000089887 @default.
- W2892387910 cites W2000211667 @default.
- W2892387910 cites W2003264522 @default.
- W2892387910 cites W2009307055 @default.
- W2892387910 cites W2010135607 @default.
- W2892387910 cites W2010360184 @default.
- W2892387910 cites W2010399610 @default.
- W2892387910 cites W2014571267 @default.
- W2892387910 cites W2014631152 @default.
- W2892387910 cites W2016921003 @default.
- W2892387910 cites W2018380441 @default.
- W2892387910 cites W2018403844 @default.
- W2892387910 cites W2025630579 @default.
- W2892387910 cites W2026596958 @default.
- W2892387910 cites W2027983860 @default.
- W2892387910 cites W2033392872 @default.
- W2892387910 cites W2036504837 @default.
- W2892387910 cites W2042112135 @default.
- W2892387910 cites W2043099341 @default.
- W2892387910 cites W2047726806 @default.
- W2892387910 cites W2053032491 @default.
- W2892387910 cites W2053186448 @default.
- W2892387910 cites W2053693558 @default.
- W2892387910 cites W2055710758 @default.
- W2892387910 cites W2056975261 @default.
- W2892387910 cites W2057656026 @default.
- W2892387910 cites W2059455603 @default.
- W2892387910 cites W2072945114 @default.
- W2892387910 cites W2077321631 @default.
- W2892387910 cites W2080012496 @default.
- W2892387910 cites W2080314503 @default.
- W2892387910 cites W2097092816 @default.
- W2892387910 cites W2097221031 @default.
- W2892387910 cites W2103562758 @default.
- W2892387910 cites W2114426273 @default.
- W2892387910 cites W2116030627 @default.
- W2892387910 cites W2118775337 @default.
- W2892387910 cites W2120883919 @default.
- W2892387910 cites W2121408179 @default.
- W2892387910 cites W2127390564 @default.
- W2892387910 cites W2129046210 @default.
- W2892387910 cites W2129125583 @default.
- W2892387910 cites W2129665625 @default.
- W2892387910 cites W2140672266 @default.
- W2892387910 cites W2144416125 @default.
- W2892387910 cites W2154201727 @default.
- W2892387910 cites W2154758745 @default.
- W2892387910 cites W2156801294 @default.
- W2892387910 cites W2157249292 @default.
- W2892387910 cites W2157879862 @default.
- W2892387910 cites W2159888619 @default.
- W2892387910 cites W2163393328 @default.
- W2892387910 cites W2166872516 @default.
- W2892387910 cites W2171791938 @default.
- W2892387910 cites W2230408745 @default.
- W2892387910 cites W2256165994 @default.
- W2892387910 cites W2311539200 @default.
- W2892387910 cites W2343651680 @default.
- W2892387910 cites W2406215809 @default.
- W2892387910 cites W2418145473 @default.
- W2892387910 cites W2478083248 @default.
- W2892387910 cites W2486966212 @default.
- W2892387910 cites W2538208843 @default.
- W2892387910 cites W2584473462 @default.
- W2892387910 cites W2602954898 @default.
- W2892387910 cites W2611938952 @default.
- W2892387910 cites W2684302385 @default.
- W2892387910 cites W2744294167 @default.
- W2892387910 cites W2773808722 @default.
- W2892387910 cites W4244528771 @default.
- W2892387910 doi "https://doi.org/10.1016/j.fct.2018.09.052" @default.
- W2892387910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30253246" @default.
- W2892387910 hasPublicationYear "2018" @default.
- W2892387910 type Work @default.