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- W2892390537 endingPage "2937" @default.
- W2892390537 startingPage "2937" @default.
- W2892390537 abstract "Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular senescence is a homeostatic biological process that has a key role in driving ageing. There is evidence that senescent cells accumulate in the nervous system with ageing and neurodegenerative disease and may predispose a person to the appearance of a neurodegenerative condition or may aggravate its course. Research into senescence has long been hindered by its variable and cell-type specific features and the lack of a universal marker to unequivocally detect senescent cells. Recent advances in senescence markers and genetically modified animal models have boosted our knowledge on the role of cellular senescence in ageing and age-related disease. The aim now is to fully elucidate its role in neurodegeneration in order to efficiently and safely exploit cellular senescence as a therapeutic target. Here, we review evidence of cellular senescence in neurons and glial cells and we discuss its putative role in Alzheimer’s disease, Parkinson’s disease and multiple sclerosis and we provide, for the first time, evidence of senescence in neurons and glia in multiple sclerosis, using the novel GL13 lipofuscin stain as a marker of cellular senescence." @default.
- W2892390537 created "2018-10-05" @default.
- W2892390537 creator A5015903333 @default.
- W2892390537 creator A5016235730 @default.
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- W2892390537 creator A5033937287 @default.
- W2892390537 creator A5047037447 @default.
- W2892390537 creator A5060105994 @default.
- W2892390537 date "2018-09-27" @default.
- W2892390537 modified "2023-10-14" @default.
- W2892390537 title "Ageing, Cellular Senescence and Neurodegenerative Disease" @default.
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