FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892391693> ?p ?o ?g. }

• W2892391693 endingPage "4720" @default.
• W2892391693 startingPage "4720" @default.
• W2892391693 abstract "Organ cultures of rabbit corneas have been used to ascertain the effectiveness of a human fibroblast growth factor (FGF)-1 derivative (TTHX1114), lacking cysteine residues, to protect against and/or repair epithelial lesions following exposure to nitrogen mustard (NM).Rabbit corneas were exposed to NM and cultured for up to 14 days, with or without drug (TTHX1114). At specified times, tissue was examined by histopathology and graded by a novel composite scale. Proliferation was measured by 5-ethynyl-2'-deoxyuridine (EdU) incorporation, and the expression of native FGF-1 and ADAM-17 after NM exposure was determined by immunofluorescence.Rabbit corneas, exposed to a single dose of NM, showed a nearly complete loss of epithelial cells by day 6 but were significantly regenerated by day 14. When treated continuously with TTHX1114 following vesicant exposure, the losses remained at day 2 levels. The loss of keratocytes in the stroma was not affected by TTHX1114. EdU incorporation over the same time course showed a steady increase in tissue that had not been treated with TTHX1114, while corneas that were treated with the drug showed a higher percent incorporation initially, which then decreased, indicating the strong proliferative response to TTHX1114. ADAM-17 was not significantly altered by TTHX1114 treatment. Corneal epithelial FGF-1 disappeared after only 1 day following exposure to NM.TTHX1114 is protective against NM-induced damage of the corneal epithelium, possibly by supplying an NM-resistant source of trophic support and by stimulating regeneration of new epithelial cells. These responses underscore the potential value of TTHX1114 as an anti-vesicant therapeutic." @default.
• W2892391693 created "2018-10-05" @default.
• W2892391693 creator A5029754189 @default.
• W2892391693 creator A5031042394 @default.
• W2892391693 creator A5038453915 @default.
• W2892391693 creator A5039590452 @default.
• W2892391693 creator A5048022663 @default.
• W2892391693 creator A5048848487 @default.
• W2892391693 creator A5052231842 @default.
• W2892391693 date "2018-09-25" @default.
• W2892391693 modified "2023-09-24" @default.
• W2892391693 title "An Engineered Human Fibroblast Growth Factor-1 Derivative, TTHX1114, Ameliorates Short-term Corneal Nitrogen Mustard Injury in Rabbit Organ Cultures" @default.
• W2892391693 cites W1174981037 @default.
• W2892391693 cites W150358514 @default.
• W2892391693 cites W1510220731 @default.
• W2892391693 cites W1655632696 @default.
• W2892391693 cites W1824333800 @default.
• W2892391693 cites W1969776715 @default.
• W2892391693 cites W1983279888 @default.
• W2892391693 cites W1988292444 @default.
• W2892391693 cites W1991762622 @default.
• W2892391693 cites W1993023753 @default.
• W2892391693 cites W1995437913 @default.
• W2892391693 cites W2008174709 @default.
• W2892391693 cites W2016480679 @default.
• W2892391693 cites W2054195724 @default.
• W2892391693 cites W2059786327 @default.
• W2892391693 cites W2071694421 @default.
• W2892391693 cites W2071833447 @default.
• W2892391693 cites W2078072567 @default.
• W2892391693 cites W2093633151 @default.
• W2892391693 cites W209488500 @default.
• W2892391693 cites W2123215877 @default.
• W2892391693 cites W2131206694 @default.
• W2892391693 cites W2134883909 @default.
• W2892391693 cites W2137559379 @default.
• W2892391693 cites W2145072523 @default.
• W2892391693 cites W2168056522 @default.
• W2892391693 cites W2304138548 @default.
• W2892391693 cites W2315070169 @default.
• W2892391693 cites W2316159156 @default.
• W2892391693 cites W2317208784 @default.
• W2892391693 cites W2325111022 @default.
• W2892391693 cites W2426503034 @default.
• W2892391693 cites W2469807257 @default.
• W2892391693 cites W2334677270 @default.
• W2892391693 doi "https://doi.org/10.1167/iovs.18-24568" @default.
• W2892391693 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6155473" @default.
• W2892391693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30267094" @default.
• W2892391693 hasPublicationYear "2018" @default.
• W2892391693 type Work @default.
• W2892391693 sameAs 2892391693 @default.
• W2892391693 citedByCount "10" @default.
• W2892391693 countsByYear W28923916932020 @default.
• W2892391693 countsByYear W28923916932021 @default.
• W2892391693 countsByYear W28923916932022 @default.
• W2892391693 countsByYear W28923916932023 @default.
• W2892391693 crossrefType "journal-article" @default.
• W2892391693 hasAuthorship W2892391693A5029754189 @default.
• W2892391693 hasAuthorship W2892391693A5031042394 @default.
• W2892391693 hasAuthorship W2892391693A5038453915 @default.
• W2892391693 hasAuthorship W2892391693A5039590452 @default.
• W2892391693 hasAuthorship W2892391693A5048022663 @default.
• W2892391693 hasAuthorship W2892391693A5048848487 @default.
• W2892391693 hasAuthorship W2892391693A5052231842 @default.
• W2892391693 hasBestOaLocation W28923916931 @default.
• W2892391693 hasConcept C142724271 @default.
• W2892391693 hasConcept C153911025 @default.
• W2892391693 hasConcept C159654299 @default.
• W2892391693 hasConcept C16685009 @default.
• W2892391693 hasConcept C169760540 @default.
• W2892391693 hasConcept C170493617 @default.
• W2892391693 hasConcept C178790620 @default.
• W2892391693 hasConcept C185592680 @default.
• W2892391693 hasConcept C202751555 @default.
• W2892391693 hasConcept C203014093 @default.
• W2892391693 hasConcept C204232928 @default.
• W2892391693 hasConcept C2775960820 @default.
• W2892391693 hasConcept C2776694085 @default.
• W2892391693 hasConcept C2776755627 @default.
• W2892391693 hasConcept C2776882836 @default.
• W2892391693 hasConcept C2777111502 @default.
• W2892391693 hasConcept C2777587049 @default.
• W2892391693 hasConcept C2778236600 @default.
• W2892391693 hasConcept C2778670039 @default.
• W2892391693 hasConcept C2779257441 @default.
• W2892391693 hasConcept C2780269544 @default.
• W2892391693 hasConcept C2780381497 @default.
• W2892391693 hasConcept C2780644109 @default.
• W2892391693 hasConcept C28483552 @default.
• W2892391693 hasConcept C29730261 @default.
• W2892391693 hasConcept C52124034 @default.
• W2892391693 hasConcept C529295009 @default.
• W2892391693 hasConcept C54355233 @default.
• W2892391693 hasConcept C544855455 @default.
• W2892391693 hasConcept C552990157 @default.
• W2892391693 hasConcept C55493867 @default.
• W2892391693 hasConcept C71924100 @default.

• next