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- W2892395013 abstract "More than 90% of thyroid cancer belongs to the papillary and follicular thyroid carcinomas based on pathological subtypes. Papillary and follicular thyroid carcinoma are generally associated with a good prognosis. In contrast, other pathological subtypes such as poorly-differentiated and anaplastic thyroid carcinoma (PDTC and ATC) have a poor clinical outcome with a short life expectancy. To identify the genetic variations and biomarkers that may potentially distinguish the aggressive form of thyroid cancer, we performed a retrospective analysis of the formalin-fixed paraffin-embedded tumor samples from 50 patients who mainly displayed aggressive thyroid cancer using next-generation sequencing of 416 solid tumor-related genes. We adopted extensive bioinformatic analysis to vigorously remove germline single-nucleotide polymorphism and systematic sequencing errors, and report here that mutation in DNMT3A gene was significantly enriched in patients with PDTC or ATC." @default.
- W2892395013 created "2018-10-05" @default.
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- W2892395013 date "2018-09-25" @default.
- W2892395013 modified "2023-09-27" @default.
- W2892395013 title "Mutations of genes including <i>DNMT3A</i> detected by next-generation sequencing in thyroid cancer" @default.
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- W2892395013 doi "https://doi.org/10.1080/15384047.2018.1523856" @default.
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