Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892399229> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2892399229 abstract "Various mesenchymal cell types have been identified as critical components of the hematopoietic stem/progenitor cell (HSPC) niche. Although several groups have described the generation of mesenchyme from human pluripotent stem cells (hPSCs), the capacity of such cells to support hematopoiesis has not been reported. Here, we demonstrate that distinct mesenchymal subpopulations co-emerge from mesoderm during hPSC differentiation. Despite co-expression of common mesenchymal markers (CD73, CD105, CD90, and PDGFRβ), a subset of cells defined as CD146hiCD73hi expressed genes associated with the HSPC niche and supported the maintenance of functional HSPCs ex vivo, while CD146loCD73lo cells supported differentiation. Stromal support of HSPCs was contact dependent and mediated in part through high JAG1 expression and low WNT signaling. Molecular profiling revealed significant transcriptional similarity between hPSC-derived CD146++ and primary human CD146++ perivascular cells. The derivation of functionally diverse types of mesenchyme from hPSCs opens potential avenues to model the HSPC niche and develop PSC-based therapies." @default.
- W2892399229 created "2018-10-05" @default.
- W2892399229 creator A5009111612 @default.
- W2892399229 creator A5025393610 @default.
- W2892399229 creator A5040485370 @default.
- W2892399229 creator A5050736924 @default.
- W2892399229 creator A5063403085 @default.
- W2892399229 creator A5064930900 @default.
- W2892399229 creator A5065558897 @default.
- W2892399229 creator A5068956158 @default.
- W2892399229 date "2018-01-04" @default.
- W2892399229 modified "2023-10-04" @default.
- W2892399229 title "Transcriptionally and Functionally Distinct Mesenchymal Subpopulations Are Generated from Human Pluripotent Stem Cells" @default.
- W2892399229 hasPublicationYear "2018" @default.
- W2892399229 type Work @default.
- W2892399229 sameAs 2892399229 @default.
- W2892399229 citedByCount "0" @default.
- W2892399229 crossrefType "journal-article" @default.
- W2892399229 hasAuthorship W2892399229A5009111612 @default.
- W2892399229 hasAuthorship W2892399229A5025393610 @default.
- W2892399229 hasAuthorship W2892399229A5040485370 @default.
- W2892399229 hasAuthorship W2892399229A5050736924 @default.
- W2892399229 hasAuthorship W2892399229A5063403085 @default.
- W2892399229 hasAuthorship W2892399229A5064930900 @default.
- W2892399229 hasAuthorship W2892399229A5065558897 @default.
- W2892399229 hasAuthorship W2892399229A5068956158 @default.
- W2892399229 hasConcept C10205521 @default.
- W2892399229 hasConcept C104317684 @default.
- W2892399229 hasConcept C107459253 @default.
- W2892399229 hasConcept C109159458 @default.
- W2892399229 hasConcept C116716535 @default.
- W2892399229 hasConcept C137620995 @default.
- W2892399229 hasConcept C145103041 @default.
- W2892399229 hasConcept C148738053 @default.
- W2892399229 hasConcept C198826908 @default.
- W2892399229 hasConcept C201750760 @default.
- W2892399229 hasConcept C2776340970 @default.
- W2892399229 hasConcept C2779093498 @default.
- W2892399229 hasConcept C2780915607 @default.
- W2892399229 hasConcept C28328180 @default.
- W2892399229 hasConcept C54355233 @default.
- W2892399229 hasConcept C62478195 @default.
- W2892399229 hasConcept C86803240 @default.
- W2892399229 hasConcept C95444343 @default.
- W2892399229 hasConceptScore W2892399229C10205521 @default.
- W2892399229 hasConceptScore W2892399229C104317684 @default.
- W2892399229 hasConceptScore W2892399229C107459253 @default.
- W2892399229 hasConceptScore W2892399229C109159458 @default.
- W2892399229 hasConceptScore W2892399229C116716535 @default.
- W2892399229 hasConceptScore W2892399229C137620995 @default.
- W2892399229 hasConceptScore W2892399229C145103041 @default.
- W2892399229 hasConceptScore W2892399229C148738053 @default.
- W2892399229 hasConceptScore W2892399229C198826908 @default.
- W2892399229 hasConceptScore W2892399229C201750760 @default.
- W2892399229 hasConceptScore W2892399229C2776340970 @default.
- W2892399229 hasConceptScore W2892399229C2779093498 @default.
- W2892399229 hasConceptScore W2892399229C2780915607 @default.
- W2892399229 hasConceptScore W2892399229C28328180 @default.
- W2892399229 hasConceptScore W2892399229C54355233 @default.
- W2892399229 hasConceptScore W2892399229C62478195 @default.
- W2892399229 hasConceptScore W2892399229C86803240 @default.
- W2892399229 hasConceptScore W2892399229C95444343 @default.
- W2892399229 hasLocation W28923992291 @default.
- W2892399229 hasOpenAccess W2892399229 @default.
- W2892399229 hasPrimaryLocation W28923992291 @default.
- W2892399229 hasRelatedWork W1146236976 @default.
- W2892399229 hasRelatedWork W1979339333 @default.
- W2892399229 hasRelatedWork W1982736212 @default.
- W2892399229 hasRelatedWork W1989259691 @default.
- W2892399229 hasRelatedWork W1998704756 @default.
- W2892399229 hasRelatedWork W2007216549 @default.
- W2892399229 hasRelatedWork W2049737261 @default.
- W2892399229 hasRelatedWork W2052946658 @default.
- W2892399229 hasRelatedWork W2055248690 @default.
- W2892399229 hasRelatedWork W2064813555 @default.
- W2892399229 hasRelatedWork W2082807958 @default.
- W2892399229 hasRelatedWork W2088762182 @default.
- W2892399229 hasRelatedWork W2155733789 @default.
- W2892399229 hasRelatedWork W2781926475 @default.
- W2892399229 hasRelatedWork W2792799981 @default.
- W2892399229 hasRelatedWork W2793413891 @default.
- W2892399229 hasRelatedWork W2807405419 @default.
- W2892399229 hasRelatedWork W3131308011 @default.
- W2892399229 hasRelatedWork W3210658222 @default.
- W2892399229 hasRelatedWork W2288628458 @default.
- W2892399229 isParatext "false" @default.
- W2892399229 isRetracted "false" @default.
- W2892399229 magId "2892399229" @default.
- W2892399229 workType "article" @default.