Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892400666> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2892400666 abstract "The LDLR plays a key role in cholesterol homeostasis. LDLR mutations cause familial hypercholesterolemia and premature coronary heart disease. Genetic deletion of the LDLR induces atherosclerosis in mice fed a high-fat diet. LDLR expression is predominantly regulated by SREBP2. PPARα and PPARγ, ligand-activated transcription factors regulating energy homeostasis and lipid metabolism, are anti-atherogenic in human and mouse models of atherosclerosis. We investigated the effects of activation of PPARα and PPARγ on LDLR expression in mouse hepatocytes and liver. Treatment of HepG2 cells with fenofibrate, a PPARα ligand, or troglitazone, a PPARγ ligand, induced expression of LDLR mRNA and protein, increased LDL binding and restored LDLR expression inhibited by LDL and 25-hydroxycholesterol. Activation of PPARα and PPARγ increased the maturation of SREBP2 and was dependent on phosphorylation of Akt. In vivo, a high-fat diet suppressed LDLR expression in mouse liver and elevated plasma LDL-cholesterol; however, fenofibrate and troglitazone restored the high-fat diet-inhibited hepatic LDLR expression and reduced plasma LDL cholesterol. Taken together, our data suggest PPARα and PPARγ ligands activate Akt phosphorylation leading to increased hepatic LDLR expression and reduced plasma LDL cholesterol levels. Supported by NHLBI PO1-HL072942/The Silbermann and Abercrombie Foundations." @default.
- W2892400666 created "2018-10-05" @default.
- W2892400666 creator A5028507446 @default.
- W2892400666 creator A5029645367 @default.
- W2892400666 creator A5061554211 @default.
- W2892400666 creator A5068202304 @default.
- W2892400666 creator A5072816186 @default.
- W2892400666 creator A5089053594 @default.
- W2892400666 date "2007-01-01" @default.
- W2892400666 modified "2023-10-12" @default.
- W2892400666 title "Activation of PPARα and PPARγ induce expression of the hepatic LDL receptor" @default.
- W2892400666 doi "https://doi.org/10.1096/fasebj.21.6.a1137" @default.
- W2892400666 hasPublicationYear "2007" @default.
- W2892400666 type Work @default.
- W2892400666 sameAs 2892400666 @default.
- W2892400666 citedByCount "1" @default.
- W2892400666 crossrefType "journal-article" @default.
- W2892400666 hasAuthorship W2892400666A5028507446 @default.
- W2892400666 hasAuthorship W2892400666A5029645367 @default.
- W2892400666 hasAuthorship W2892400666A5061554211 @default.
- W2892400666 hasAuthorship W2892400666A5068202304 @default.
- W2892400666 hasAuthorship W2892400666A5072816186 @default.
- W2892400666 hasAuthorship W2892400666A5089053594 @default.
- W2892400666 hasConcept C126322002 @default.
- W2892400666 hasConcept C134018914 @default.
- W2892400666 hasConcept C170493617 @default.
- W2892400666 hasConcept C185592680 @default.
- W2892400666 hasConcept C187345961 @default.
- W2892400666 hasConcept C2778110834 @default.
- W2892400666 hasConcept C2778150266 @default.
- W2892400666 hasConcept C2778163477 @default.
- W2892400666 hasConcept C2780072125 @default.
- W2892400666 hasConcept C43554185 @default.
- W2892400666 hasConcept C71924100 @default.
- W2892400666 hasConcept C86803240 @default.
- W2892400666 hasConceptScore W2892400666C126322002 @default.
- W2892400666 hasConceptScore W2892400666C134018914 @default.
- W2892400666 hasConceptScore W2892400666C170493617 @default.
- W2892400666 hasConceptScore W2892400666C185592680 @default.
- W2892400666 hasConceptScore W2892400666C187345961 @default.
- W2892400666 hasConceptScore W2892400666C2778110834 @default.
- W2892400666 hasConceptScore W2892400666C2778150266 @default.
- W2892400666 hasConceptScore W2892400666C2778163477 @default.
- W2892400666 hasConceptScore W2892400666C2780072125 @default.
- W2892400666 hasConceptScore W2892400666C43554185 @default.
- W2892400666 hasConceptScore W2892400666C71924100 @default.
- W2892400666 hasConceptScore W2892400666C86803240 @default.
- W2892400666 hasFunder F4320337338 @default.
- W2892400666 hasIssue "6" @default.
- W2892400666 hasLocation W28924006661 @default.
- W2892400666 hasOpenAccess W2892400666 @default.
- W2892400666 hasPrimaryLocation W28924006661 @default.
- W2892400666 hasRelatedWork W1965393911 @default.
- W2892400666 hasRelatedWork W2004744807 @default.
- W2892400666 hasRelatedWork W2019813684 @default.
- W2892400666 hasRelatedWork W2021208588 @default.
- W2892400666 hasRelatedWork W2045971133 @default.
- W2892400666 hasRelatedWork W2087122397 @default.
- W2892400666 hasRelatedWork W2140626451 @default.
- W2892400666 hasRelatedWork W2166236611 @default.
- W2892400666 hasRelatedWork W2202798660 @default.
- W2892400666 hasRelatedWork W2373128075 @default.
- W2892400666 hasVolume "21" @default.
- W2892400666 isParatext "false" @default.
- W2892400666 isRetracted "false" @default.
- W2892400666 magId "2892400666" @default.
- W2892400666 workType "article" @default.