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- W2892401042 abstract "Hypoxia is a common phenomenon in the majority of solid tumours, thereby contributing to progression, angiogenesis, invasion, and metastasis of tumours. The authors synthesised a hypoxia-responsive (HR) magnetic iron oxide nanoparticles (IONPs) as drug delivery system by incorporating a hypoxia moiety (azobenzene) between IONPs and drug. The obtained drug delivery system showed sustained release under normoxic conditions, while a controlled release was observed under hypoxic condition due to the cleavage of azobenzene. More than 80% of the drug was released in 4 h after hypoxic treatment, leading to a high cytotoxicity. Thus, this HR magnetic drug delivery system had the potential for future applications in the treatment of hypoxic tumours and other hypoxia-related diseases." @default.
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- W2892401042 date "2019-01-01" @default.
- W2892401042 modified "2023-09-24" @default.
- W2892401042 title "Preparation of HR magnetic IONPs for drug delivery" @default.
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- W2892401042 doi "https://doi.org/10.1049/mnl.2018.5263" @default.
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