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• W2892401646 abstract "Glioma is a highly malignant tumor that starts in the glial cells of brain. Tumor cells reproduce quickly and infiltrate rapidly in high grade glioma. Permeability of chemotherapeutic agents into brain is restricted owing to the presence of blood brain barrier (BBB). In this study, we developed a dual functionalized liposomal delivery system for efficient transport of chemotherapeutics across BBB for the treatment of glioma. Liposomes were surface modified with transferrin (Tf) for receptor targeting, and cell penetrating peptide PFVYLI (PFV) to increase translocation of doxorubicin (Dox) and Erlotinib (Erlo) across the BBB into glioblastoma (U87) tumor cells. In vitro cytotoxicity and hemolysis studies were performed to assess biocompatibility of liposomal nanoparticles. Cellular uptake studies demonstrated efficient internalization of Dox and Erlo in U87, brain endothelial (bEnd.3), and glial cells. In addition, dual functionalized liposomes showed significantly (p < 0.05) higher apoptosis in U87 cells. Significantly (p < 0.05) higher translocation of dual functionalized liposomes across the BBB and delivering chemotherapeutic drugs to the glioblastoma tumor cells inside PLGA-Chitosan scaffold resulted in approximately 52% tumor cell death, using in vitro brain tumor model." @default.
• W2892401646 created "2018-10-05" @default.
• W2892401646 creator A5019359010 @default.
• W2892401646 creator A5035758532 @default.
• W2892401646 date "2019-01-01" @default.
• W2892401646 modified "2023-09-30" @default.
• W2892401646 title "Co-delivery of doxorubicin and erlotinib through liposomal nanoparticles for glioblastoma tumor regression using an in vitro brain tumor model" @default.
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• W2892401646 doi "https://doi.org/10.1016/j.colsurfb.2018.09.047" @default.
• W2892401646 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6296250" @default.
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• W2892401646 hasPublicationYear "2019" @default.
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