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- W2892416084 abstract "The field of glycoscience explores the structures and functions of carbohydrates that calls for the rapid access of structurally defined oligosaccharides. In contrast to the synthesis of nucleic acids and peptides/proteins, synthetic preparation of carbohydrates remains laborious that necessitates the development of novel yet robust synthetic strategy to achieve automated oligosaccharide synthesis.In PART A of this thesis, we report our recent developments of a novel glycosylation method based on a designer thioglycoside that can be activated by catalytic amount of carbophilic Lewis acid. Furthermore, in two separate strategies i.e. 1) catalytic reactivity-based one-pot glycosylation and 2) sequential active-latent strategy for glycosylation, we will demonstrate the synthetic utility of our new methodology. We also identified perfluoroamide based linker in biomolecule synthesis. The fluorous solid phase extraction facilitates the solution-phase rapid oligosaccharide assembly. Gold-catalyzed glycosylation, clubbed with perfluoroamide linker/tag appeared to be an ideal recipe in the context of convenient combinatorial access to biologically important carbohydrate molecules. In PART B, I address the important issue associated with the functions of carbohydrate modification in dystroglycan (DG) in muscular dystrophies (MDs), a group of muscle diseases, for which currently no cure is available. Sorting out the relationships between the various molecular defects in glycosylation and the modes of disease presentation is challenging. The enzymatic oligosaccharide product from LARGE gene has been recently identified, which consists of a repeating (13)-GlcUA--(13)-Xyl disaccharide unit. A template directed 1,2-cis glycosylation was utilized to synthesize a series of a-DG associated glycans. Additionally, a successful synthesis is demonstrated for B4GAT1 enzymatic trisaccharide, which is also found to be involved in post-translational modification. We expect our study serve as the basis for finding novel medical solutions to neurological diseases that commonly causes cardiac muscle dystrophies and brain diseases." @default.
- W2892416084 created "2018-10-05" @default.
- W2892416084 creator A5067626797 @default.
- W2892416084 date "2017-09-29" @default.
- W2892416084 modified "2023-09-27" @default.
- W2892416084 title "DEVELOPMENT OF CATALYTIC GLYCOSYLATION METHOD FOR OLIGOSACCHARIDE ASSEMBLY AND TOTAL SYNTHESIS OF ACIDIC ALPHA-DYSTROGLYCAN OLIGOSACCHARIDES" @default.
- W2892416084 hasPublicationYear "2017" @default.
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